PADI1 Antibody Cat. No.: 13-459

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse
IMMUNOGEN: Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PADI1 (NP_037490.2).
TESTED APPLICATIONS: WB
APPLICATIONS: WB: ,1:200 - 1:1000
POSITIVE CONTROL:1) A-431
 2) SW480
 3) U-937
 4) HepG2
 5) Mouse liver
PREDICTED MOLECULAR WEIGHT: Observed: 65kDa

psi-iconProperties
PURIFICATION:Affinity purification
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
STORAGE CONDITIONS:Store at -20˚C. Avoid freeze / thaw cycles.

psi-iconAdditional Info
OFFICIAL SYMBOL:PADI1
ALTERNATE NAMES:HPAD1PAD1, PDI, PDI1, protein-arginine deiminase type-1, hPAD-colony 1peptidyl arginine deiminase, type I, peptidylarginine deiminase I, protein-arginine deiminase type I
GENE ID:29943
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes.

ANTIBODIES FOR RESEARCH USE ONLY.

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