OX40 Ligand Recombinant Protein Cat. No.: 40-317

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SOURCE SPECIES:High-5 Insect cells
BIOLOGICAL ACTIVITY: Biological activity was determined by its ability to stimulate IL - 8 production by human PBMC using a concentration range of 30 - 100 ng/mL. Note: Results may vary with PBMC donors.
PURITY:Greater than 97% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
STORAGE CONDITIONS:The lyophilized OX40 Ligand recombinant protein is stable for at least 2 years from date of receipt at -20˚C. Reconstituted OX40 Ligand is stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚C. As with any protein, exposing OX40 Ligand recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
psi-iconAdditional Info
ALTERNATE NAMES:GP34, CD252, OX4OL, TXGP1, CD134L, OX-40L, Tumor necrosis factor ligand superfamily member 4, Glycoprotein Gp34, OX40L
PROTEIN GI NO.:4507603
GENE ID:7292
psi-iconBackground and References
BACKGROUND:OX40L, a member of the TNF superfamily of structurally related proteins, exists primarily as a type II membrane bound, non-covalently linked homotrimeric protein. It is expressed on antigen presenting cells (APCs), such as dendritic cells and activated B-cells, and also on various other cells such as vascular endothelial cells, mast cells, and natural killer cells. OX40L signals specifically through the OX40 receptor, which is expressed predominantly on CD4+T cells but also on certain activated CD8+T cells. OX40/OX40L functions as a costimulatory signal, which is required for a productive interaction between antigen presenting cells and their target T-cells. It enhances cell proliferation and survival, and increases expression of RANTES, IL-2, IL-3, and IFNγ. OX40/OX40L signaling plays an important role in immuno-regulatory communication, enabling the immune system to distinguish between "friend vs. foe” during activation; a mechanism typically termed immuno-tolerance. Recombinant OX40L is a glycosylated 133 amino acid protein corresponding to the extracellular TNF homologous domain of the full length transmembrane protein. It migrates with an apparent molecular mass of 15.5 - 25.0 kDa on SDS-PAGE.


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