NEU1 Antibody Cat. No.: 60-825

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human
HOMOLOGY: Predicted species reactivity based on immunogen sequence: Bovine
IMMUNOGEN: This NEU1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-214 amino acids from the Central region of human NEU1.
TESTED APPLICATIONS: WB
APPLICATIONS: For WB starting dilution is: 1:1000
PREDICTED MOLECULAR WEIGHT: 45 kDa

psi-iconProperties
PURIFICATION:This antibody is purified through a protein A column, followed by peptide affinity purification.
CLONALITY:Polyclonal
ISOTYPE:Rabbit Ig
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Supplied in PBS with 0.09% (W/V) sodium azide.
CONCENTRATION:batch dependent
STORAGE CONDITIONS:Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:NEU1
ALTERNATE NAMES:Sialidase-1, Acetylneuraminyl hydrolase, G9 sialidase, Lysosomal sialidase, N-acetyl-alpha-neuraminidase 1, NEU1, NANH
ACCESSION NO.:Q99519
PROTEIN GI NO.:17368612
GENE ID:4758
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity.
REFERENCES:1) Caciotti, A., et al. J. Neurol. 256(11):1911-1915(2009)
2) Bonten, E.J., et al. J. Biol. Chem. 284(41):28430-28441(2009)
3) Barcellos, L.F., et al. PLoS Genet.(10), E1000696 (2009) :
4) Wang, J., et al. J. Neurochem. 111(2):547-554(2009)

ANTIBODIES FOR RESEARCH USE ONLY.

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