Netrin-1 Recombinant Protein Cat. No.: 90-247

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psi-iconSpecifications
SPECIES:Human, Mouse, Rat
SOURCE SPECIES:HEK293 cells
SEQUENCE:Human netrin-1 (aa 25-604) is fused at the C-terminus to a DDDDK-tag.
FUSION TAG:DDDDK Tag
TESTED APPLICATIONS:
APPLICATIONS:This recombinant proteins is for research use only.
BIOLOGICAL ACTIVITY: Induces pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by inhibiting apoptosis mediated by the receptors DCC or UNC5B (at 150ng /ml). Induces axon outgrowth.
psi-iconProperties
PURITY:>95% (SDS-PAGE).

Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza).
PHYSICAL STATE:Lyophilized
BUFFER:Contains PBS plus protein stabilizer. No BSA included. The protein stabilizer shows no interference with protein activity. Reconstitute with 100 μl sterile distilled water.
CONCENTRATION:0.1mg/ml after reconstitution.
STORAGE CONDITIONS:Stable for at least 6 months after receipt when stored at -20˚C.
psi-iconAdditional Info
ALTERNATE NAMES:NTN1
ACCESSION NO.:O95631
PROTEIN GI NO.:148613884
OFFICIAL SYMBOL:NTN1
GENE ID:9423
psi-iconBackground and References
BACKGROUND:Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also Involved in tumorigenesis by regulating apoptosis.

FOR RESEARCH USE ONLY.

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