Datasheet

NALP14 Antibody
CATALOG NUMBER: 5975

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:NALP14 antibody can be used for detection of NALP14 by Western blot at 1 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1463 - Rat Brain Tissue Lysate
IMMUNOGEN:NALP14 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human NALP14.

The immunogen is located within amino acids 200 - 250 of NALP14.
HOST SPECIES:Rabbit

Properties

PURIFICATION:NALP14 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:NALP14 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:NALP14 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:NALP14 Antibody: NOD5, PAN8, GC-LRR, NALP14, CLR11.2, NOD5, NACHT, LRR and PYD domains-containing protein 14, Nucleotide-binding oligomerization domain protein 5
ACCESSION NO.:NP_789792
PROTEIN GI NO.:28827813
OFFICIAL SYMBOL:NLRP14
GENE ID:338323

Background

BACKGROUND:NALP14 Antibody: NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP14 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. While little is known about the function of NALP14, it has been suggested that it may play a role in spermatogenesis and that mutations in the NALP14 gene might cause spermatogenic failure.
REFERENCES: 1) Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol.2003; 4:95-104.
2) Tian X, Pascal G, and Monget P. Evolution and functional divergence of NLRP genes in mammalian reproductive system. BMC Evol. Biol.2009; 9:202.
3) Westerveld GH, Korver CM, van Pelt AMM, et al. Mutations in the tesits-specific NALP14 gene in men suffering from spermatogenic failure. Hum. Reprod.2006; 21:3178-84.

For Research Use Only