Datasheet

NALP11 Antibody
CATALOG NUMBER: 5969

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human
TESTED APPLICATIONS:ELISA, ICC, IF, WB
APPLICATIONS:NALP11 antibody can be used for detection of NALP11 by Western blot at 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1201 - HeLa Cell Lysate
 2) Cat. No. 17-001 - HeLa Cell Slide
IMMUNOGEN:NALP11 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human NALP11.

The immunogen is located within the last 50 amino acids of NALP11.
HOST SPECIES:Rabbit

Properties

PURIFICATION:NALP11 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:NALP11 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:NALP11 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:NALP11 Antibody: NOD17, PAN10, NALP11, PYPAF6, PYPAF7, CLR19.6, NOD17, NACHT, LRR and PYD domains-containing protein 11, Nucleotide-binding oligomerization domain protein 17
ACCESSION NO.:NP_659444
PROTEIN GI NO.:194018484
OFFICIAL SYMBOL:NLRP11
GENE ID:204801

Background

BACKGROUND:NALP11 Antibody: NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP11 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. While little is known about the function of NALP11, it has been suggested that it has been associated with Crohn's disease.
REFERENCES: 1) Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol.2003; 4:95-104.
2) Tian X, Pascal G, and Monget P. Evolution and functional divergence of NLRP genes in mammalian reproductive system. BMC Evol. Biol.2009; 9:202.
3) Cummings JR, Cooney RM, Clarke G, et al. The genetics of NOD-like receptors in Crohn’s disease. Tiss. Antigens2010; 76:48-56.

For Research Use Only