Datasheet

NALP10 Antibody
CATALOG NUMBER: 5967

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human
HOMOLOGY:Predicted species reactivity based on immunogen sequence: Mouse: (83%)
TESTED APPLICATIONS:ELISA, IF, IHC-P, WB
APPLICATIONS:NALP10 antibody can be used for detection of NALP10 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1303 - Human Brain Tissue Lysate
 2) Cat. No. 10-301 - Human Brain Tissue Slide
IMMUNOGEN:NALP10 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human NALP10.

The immunogen is located within the first 50 amino acids of NALP10.
HOST SPECIES:Rabbit

Properties

PURIFICATION:NALP10 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:NALP10 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:NALP10 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:NALP10 Antibody: NOD8, PAN5, PYNOD, NALP10, CLR11.1, NOD8, NACHT, LRR and PYD domains-containing protein 10, Nucleotide-binding oligomerization domain protein 8
ACCESSION NO.:NP_789791
PROTEIN GI NO.:28827807
OFFICIAL SYMBOL:NLRP10
GENE ID:338322

Background

BACKGROUND:NALP10 Antibody: NALP proteins are cytoplasmic proteins that form a subfamily within the larger CATERPILLER family and are thought to play a crucial role in cell proliferation and reproduction. Like all other NALP family members, NALP10 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It was initially identified as PYNOD, an Apaf-1-like protein that binds to ASC, caspase-1 and IL-1β, inhibiting the autoprocessing of caspase-1, caspase-1-mediated IL-1β processing, and ASC aggregation. NALP10 is thus a potent regulator of apoptosis and inflammation.
REFERENCES: 1) Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol.2003; 4:95-104.
2) Tian X, Pascal G, and Monget P. Evolution and functional divergence of NLRP genes in mammalian reproductive system. BMC Evol. Biol.2009; 9:202.
3) Wang Y, Hasegawa M, Imamura R, et al. PYNOD,a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1. Int. Immunol.2004; 16:777-86.
4) Imamura R, Wang Y, Kinoshita T, et al. Anti-inflammatory activity of PYNOD and its mechanism in humans and mice. J. Immunol.2010; 184:5874-84.

For Research Use Only