Datasheet

MYT1L Antibody
CATALOG NUMBER: 7083

Availability: In stock

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
TESTED APPLICATIONS:ELISA, IF, WB
APPLICATIONS:MYT1L antibody can be used for detection of MYT1L by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1403 - Mouse Brain Tissue Lysate
PREDICTED MOLECULAR WEIGHT:130 kDa
SPECIFICITY:At least three isoforms are known to exist. This antibody will only recognize the two longest isoforms.
IMMUNOGEN:Rabbit polyclonal MYT1L antibody was raised against an 18 amino acid peptide near the carboxy terminus of human MYT1L.

The immunogen is located within the last 50 amino acids of MYT1L.
HOST SPECIES:Rabbit

Properties

PURIFICATION:MYT1L Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:MYT1L Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:MYT1L antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:MYT1L Antibody: NZF1, ZC2HC4B, KIAA1106, Myelin transcription factor 1-like protein, MyT1-L
ACCESSION NO.:NP_055840
PROTEIN GI NO.:60498973
OFFICIAL SYMBOL:MYT1L
GENE ID:23040

Background

BACKGROUND:MYT1L Antibody: The myelin transcription factor 1 family, to which the myelin transcription factor 1-like protein (MYT1L) belongs, is expressed primarily in the developing central nervous system and recruits histone deacetylase (HDAC) to regulate neural transcription. Both MYT1L and the related protein MYT1 interact with SIN3B, a protein that mediates transcriptional repression by binding to HDACs, suggesting that the MYT1 family favor the silencing of genes during neural development. Recent studies suggest that polymorphisms of MYT1L may be associated with schizophrenia.
REFERENCES: 1) Romm E, Nielsen JA, Kim JG, et al. Myt1 family recruits histone deacetylase to regulate neural transcription. J. Neurochem. 2005; 93:1444-53
2) Li W, Wang X, Zhao J, et al. Association study of myelin transcription factor 1-like polymorphisms with schizophrenia in Han Chinese population. Genes Brain Behav. 2012; 11:87-93.

For Research Use Only