MYT1L Antibody Cat. No.: 7083

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Rat
IMMUNOGEN: Rabbit polyclonal MYT1L antibody was raised against an 18 amino acid peptide near the carboxy terminus of human MYT1L.

The immunogen is located within the last 50 amino acids of MYT1L.
TESTED APPLICATIONS: IF
APPLICATIONS: MYT1L antibody can be used for detection of MYT1L by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in mouse samples and Immunofluorescence in human samples. All other applications and species not yet tested.
SPECIFICITY: At least three isoforms are known to exist. This antibody will only recognize the two longest isoforms.
POSITIVE CONTROL:1) Cat. No. 1403 - Mouse Brain Tissue Lysate
PREDICTED MOLECULAR WEIGHT: 130 kDa

psi-iconProperties
PURIFICATION:MYT1L Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:MYT1L Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:MYT1L antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:MYT1L
ALTERNATE NAMES:MYT1L Antibody: NZF1, ZC2HC4B, KIAA1106, Myelin transcription factor 1-like protein, MyT1-L
ACCESSION NO.:NP_055840
PROTEIN GI NO.:60498973
GENE ID:23040
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:MYT1L Antibody: The myelin transcription factor 1 family, to which the myelin transcription factor 1-like protein (MYT1L) belongs, is expressed primarily in the developing central nervous system and recruits histone deacetylase (HDAC) to regulate neural transcription. Both MYT1L and the related protein MYT1 interact with SIN3B, a protein that mediates transcriptional repression by binding to HDACs, suggesting that the MYT1 family favor the silencing of genes during neural development. Recent studies suggest that polymorphisms of MYT1L may be associated with schizophrenia.
REFERENCES:1) Romm E, Nielsen JA, Kim JG, et al. Myt1 family recruits histone deacetylase to regulate neural transcription. J. Neurochem. 2005; 93:1444-53
2) Li W, Wang X, Zhao J, et al. Association study of myelin transcription factor 1-like polymorphisms with schizophrenia in Han Chinese population. Genes Brain Behav. 2012; 11:87-93.

ANTIBODIES FOR RESEARCH USE ONLY.

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