Datasheet

MTERFD3 Antibody
CATALOG NUMBER: 7285

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse
HOMOLOGY:Predicted species reactivity based on immunogen sequence: Rat: (76%)
TESTED APPLICATIONS:ELISA, IHC-P, WB
APPLICATIONS:MTERFD3 Antibody can be used for detection of MTERFD3 by Western blot at 1 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1313 - Human Testis Tissue Lysate
PREDICTED MOLECULAR WEIGHT:Predicted: 42 kDa

Observed: 40 kDa
SPECIFICITY:MTERFD3 antibody is predicted to not cross-react with other MTERFD protein family members.
IMMUNOGEN:MTERFD3 antibody was raised against an 18 amino acid peptide near the amino terminus of human MTERFD3 .

The immunogen is located within amino acids 20 - 70 of MTERFD3.
HOST SPECIES:Rabbit

Properties

PURIFICATION:MTERFD3 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:MTERFD3 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:MTERFD3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:MTERFD3 Antibody: mTERF2, mTERFL, mTERF domain-containing protein 3, mitochondrial, Mitochondrial transcription termination factor 2, mTERF2
ACCESSION NO.:NP_079474
PROTEIN GI NO.:21314736
OFFICIAL SYMBOL:MTERFD3
GENE ID:80298

Background

BACKGROUND:MTERFD3 Antibody: Members of the mTERF (mitochondrial transcription termination factor) family, are mitochondrial proteins that are believed to be transcription termination factors. MTERFD3 was initially identified through differential display analysis and is expressed primarily in heart, liver, pancreas and skeletal muscle. MTERFD3 is believed to be involved in cell cycle regulation and cell growth by modulating mitochondrial transcription, and may be a serum-inhibitory factor.
REFERENCES: 1) Fernandez-Silva P, et al. The human mitochondrial transcription termination factor (mTERF) is a multizipper protein but binds to DNA as a monomer, with evidence pointing to intramolecular leucine zipper interactions. EMBO J. 1997; 16:1066-79.
2) Chen Y, Zhou G, Yu M, et al. Cloning and functional analysis of human mTERFL encoding a novel mitochondrial transcription termination factor-like protein. Biochem. Biophys. Res. Commun. 2005; 337:1112-8.
3) Park CB, Asin-Cayuela J, Camara Y, et al. MTERF3 is a negative regulator of mammalian mtDNA transcription. Cell 2007; 130:273-85.

For Research Use Only