MTERFD3 Antibody Cat. No.: 7285

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse
HOMOLOGY: Predicted species reactivity based on immunogen sequence: Rat: (76%)
IMMUNOGEN: MTERFD3 antibody was raised against an 18 amino acid peptide near the amino terminus of human MTERFD3 .

The immunogen is located within amino acids 20 - 70 of MTERFD3.
TESTED APPLICATIONS: ELISA, IHC-P, WB
APPLICATIONS: MTERFD3 Antibody can be used for detection of MTERFD3 by Western blot at 1 μg/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested.
SPECIFICITY: MTERFD3 antibody is predicted to not cross-react with other MTERFD protein family members.
POSITIVE CONTROL:1) Cat. No. 1313 - Human Testis Tissue Lysate
PREDICTED MOLECULAR WEIGHT: Predicted: 42 kDa

Observed: 40 kDa

psi-iconProperties
PURIFICATION:MTERFD3 Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:MTERFD3 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:MTERFD3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

psi-iconAdditional Info
OFFICIAL SYMBOL:MTERFD3
ALTERNATE NAMES:MTERFD3 Antibody: mTERF2, mTERFL, mTERF domain-containing protein 3, mitochondrial, Mitochondrial transcription termination factor 2, mTERF2
ACCESSION NO.:NP_079474
PROTEIN GI NO.:21314736
GENE ID:80298
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:MTERFD3 Antibody: Members of the mTERF (mitochondrial transcription termination factor) family, are mitochondrial proteins that are believed to be transcription termination factors. MTERFD3 was initially identified through differential display analysis and is expressed primarily in heart, liver, pancreas and skeletal muscle. MTERFD3 is believed to be involved in cell cycle regulation and cell growth by modulating mitochondrial transcription, and may be a serum-inhibitory factor.
REFERENCES:1) Fernandez-Silva P, et al. The human mitochondrial transcription termination factor (mTERF) is a multizipper protein but binds to DNA as a monomer, with evidence pointing to intramolecular leucine zipper interactions. EMBO J. 1997; 16:1066-79.
2) Chen Y, Zhou G, Yu M, et al. Cloning and functional analysis of human mTERFL encoding a novel mitochondrial transcription termination factor-like protein. Biochem. Biophys. Res. Commun. 2005; 337:1112-8.
3) Park CB, Asin-Cayuela J, Camara Y, et al. MTERF3 is a negative regulator of mammalian mtDNA transcription. Cell 2007; 130:273-85.

ANTIBODIES FOR RESEARCH USE ONLY.

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