MTCH2 Recombinant Protein Cat. No.: 95-118

Availability: In stock

$0.00

 Price Options

$0.00
psi-iconSpecifications
SPECIES:Mouse
SOURCE SPECIES:E. coli
SEQUENCE:aa 29 - 174
FUSION TAG:Fusion Partner: C-terminal His-tag
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:This recombinant protein can be used for WB and ELISA. For research use only.
BIOLOGICAL ACTIVITY: N/A
psi-iconProperties
PURITY:~95%
PREDICTED MOLECULAR WEIGHT:19 kDa (Calculated)
PHYSICAL STATE:Liquid
BUFFER:1X PBS containing 0.1% SDS
STORAGE CONDITIONS:Store in working aliquots at -70˚C. Avoid freeze/thaw cycles. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
psi-iconAdditional Info
ALTERNATE NAMES:MTCH2 Recombinant Protein: HSPC032, 2310034D24Rik, 4930539J07Rik, Mitochondrial carrier homolog 2
ACCESSION NO.:NP_055157
PROTEIN GI NO.:5815347
OFFICIAL SYMBOL:Mtch2
GENE ID:56428
psi-iconBackground and References
BACKGROUND:Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death (reviewed in 2 and 3). MTCH2 is a member of the mitochondrial carrier protein family that catalyze the exchange of substrates across the inner mitochondrial membrane and is targeted by Bid, a pro-apoptotic Bcl-2 family member, in response to apoptotic signals (4-6), suggesting that MTCH2 may play a key role in the mitochondrial apoptosis pathway. The doublet observed in the SDS-PAGE is likely due to incomplete removal of the signal sequence.
REFERENCES:1) Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ. 2000; 7:2-7.
2) Cory S, Huang DCS, and Adams JM. The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 2003; 22:8590-607.
3) Heiser D, Labi V, Erlacher M, et al. The Bcl-2 protein family and its role in the development of neoplastic disease. Exp. Geron. 2004; 39:1125-35.
4) Grinberg M, Schwarz M, Zaltsman Y, et al. Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha. Mol. Cell. Biol. 2005; 25:4579-90.

FOR RESEARCH USE ONLY.

For additional information, visit ProSci's Terms & Conditions Page.