Datasheet

MS4A6A Antibody
CATALOG NUMBER: 6593

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
TESTED APPLICATIONS:ELISA, IF, IHC-P, WB
APPLICATIONS:MS4A6A antibody can be used for detection of MS4A6A by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1210 - HEK293 Cell Lysate
SPECIFICITY:At least three isoforms of MS4A6A are known to exist; this antibody will detect the two longer isoforms. MS4A6A antibody is predicted to not cross-react with MS4A family members.
IMMUNOGEN:MS4A6A antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human MS4A6A.

The immunogen is located within the first 50 amino acids of MS4A6A.
HOST SPECIES:Rabbit

Properties

PURIFICATION:MS4A6A Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:MS4A6A Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:MS4A6A antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:MS4A6A Antibody: CDA01, MS4A6, 4SPAN3, CD20L3, MST090, MSTP090, 4SPAN3.2, CDA01, Membrane-spanning 4-domains subfamily A member 6A, CD20 antigen-like 3
ACCESSION NO.:NP_071744
PROTEIN GI NO.:23238238
OFFICIAL SYMBOL:MS4A6A
GENE ID:64231

Background

BACKGROUND:MS4A6A Antibody: The MS4A gene family in humans includes CD20 (MS4A1), FcRbeta (MS4A2), Htm4 (MS4A3), and at least 13 other genes encoding membrane proteins, most having characteristic tetraspanning topology and similar intron/exon splice boundaries. All family members display unique expression patterns among hematopoietic cells and non-lymphoid tissues. The function of MS4A6A has been suggested to be involved in signal transduction as a component of a multimeric receptor complex in Alzheimer's disease and cancer.
REFERENCES: 1) Liang Y and Tedder TF. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. Genomics 2001; 72:119-27
2) Ishibashi K, Suzuki M, Sasaki S, et al. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. Gene 2001; 264:87-93.
3) AntĂșnez C, Boada M, Gonzalez-PĂ©rez A, et al. The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease. Genome Med. 2011; 3:33
4) Hollingworth P, Harold D, Sims R, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat. Genet. 2011; 43:429-35.

For Research Use Only