MOX1 Antibody Cat. No.: 5995

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
IMMUNOGEN: MOX1 antibody was raised against a 19 amino acid synthetic peptide near the center of human MOX1.

The immunogen is located within amino acids 140 - 190 of MOX1.
TESTED APPLICATIONS: ELISA, ICC, IF, WB
APPLICATIONS: MOX1 antibody can be used for detection of MOX1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
POSITIVE CONTROL:1) Cat. No. 1304 - Human Liver Tissue Lysate

psi-iconProperties
PURIFICATION:MOX1 Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:MOX1 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:MOX1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:MEOX1
ALTERNATE NAMES:MOX1 Antibody: KFS2, MOX1, Homeobox protein MOX-1, Mesenchyme homeobox 1
ACCESSION NO.:NP_004518
PROTEIN GI NO.:4758710
GENE ID:4222
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:MOX1 Antibody: MOX1, also known as MEOX1, is a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes that is first expressed during gastrulation in the early mesoderm and later in presomitic mesoderm, early somites, dermomyotome and sclerotome. Both MOX1 and the related protein MOX2 are required for proper gene expression in all somitic compartments. MOX1 is an upstream regulator of the transcription factors Bapx1, Tbx18, and Uncx and is thus part of a regulatory circuit that functions in the maintenance of rostrocaudal sclerotome polarity and axial skeleton formation.
REFERENCES:1) Cadia AF, Hu J, Crosby J, et al. Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos. Development1992; 116:1123-36.
2) Candia AF and Wright CV. Differential localization of Mox-1 and Mox-2 proteins indicates distinct roles during development. Int. J. Dev. Biol.1996; 40:1179-84.
3) Mankoo BS, Skuntz S, Harrigan I, et al. The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning, and differentiation of somites. Development2003; 130:4655-64.
4) Skuntz S, Mankoo B, Nguyen MT, et al. Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the craniocervical joints of the axial skeleton. Dev. Biol.2009; 332:383-95.

ANTIBODIES FOR RESEARCH USE ONLY.

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