MFSD2B Antibody Cat. No.: 6027

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Rat
HOMOLOGY: Predicted species reactivity based on immunogen sequence: Mouse: (80%)
IMMUNOGEN: MFSD2B antibody was raised against a 15 amino acid synthetic peptide near the center of human MFSD2B.

The immunogen is located within amino acids 240 - 290 of MFSD2B.
TESTED APPLICATIONS: ELISA, WB
APPLICATIONS: MFSD2A antibody can be used for detection of MFSD2A by Western blot at 1 - 2 μg/mL.

Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
POSITIVE CONTROL:1) Cat. No. 1462 - Rat Lung Tissue Lysate

psi-iconProperties
PURIFICATION:MFSD2B Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:MFSD2B Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:MFSD2B antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:MFSD2B
ALTERNATE NAMES:MFSD2B Antibody: Major facilitator superfamily domain-containing protein 2B
ACCESSION NO.:NP_001073942
PROTEIN GI NO.:122937339
GENE ID:388931
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:MFSD2B Antibody: Multidrug transporters, such as MFSD2B, are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell and render cells resistant to multiple drugs. Major Facilitator Superfamily (MFS) members are capable of transporting various substrates such as sugars, polyols, drugs, neurotransmitters, amino acids, peptides, and inorganic anions, although most members are substrate-specific. MFSD2B is closely related to MFSD2A, which is expressed in many tissues and is highly induced in liver and brown adipose tissue (BAT) during fasting, playing a major role in the induction of MFSD2A expression during adaptive thermogenesis. Unlike MFSD2A, MFSD2B is expressed in few tissues and at relatively low levels, and is not induced during fasting, suggesting that MFSD2B may play other roles.
REFERENCES:1) Fluman N and Bibi E. Bacterial multidrug transport through the lens of the major facilitator superfamily. Biochim. Biophys. Acta.2009; 1794:738-47.
2) Law CJ, Maloney PC, and Wang DN. Ins and outs of major facilitator superfamily antiporters. Annu. Rev. Microbiol.2008; 62:289-305.
3) Angers M, Uldry M, Kong D, et al. Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis. Biochem. J.2008; 416:347-55

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