Datasheet

MFSD1 Antibody
CATALOG NUMBER: 6023

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
HOMOLOGY:Predicted species reactivity based on immunogen sequence: Bovine: (100%), Chicken: (78%)
TESTED APPLICATIONS:ELISA, IHC-P, WB
APPLICATIONS:MFSD1 antibody can be used for detection of MFSD1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 10 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1313 - Human Testis Tissue Lysate
IMMUNOGEN:MFSD1 antibody was raised against an 18 amino acid synthetic peptide near the center of human MFSD1.

The immunogen is located within amino acids 220 - 270 of MFSD1.
HOST SPECIES:Rabbit

Properties

PURIFICATION:MFSD1 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:MFSD1 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:MFSD1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:MFSD1 Antibody: SMAP4, SMAP4, UG0581B09, Major facilitator superfamily domain-containing protein 1, Smooth muscle cell-associated protein 4, SMAP-4
ACCESSION NO.:NP_073573
PROTEIN GI NO.:269847416
OFFICIAL SYMBOL:MFSD1
GENE ID:64747

Background

BACKGROUND:MFSD1 Antibody: Multidrug transporters, such as MFSD1, are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell and render cells resistant to multiple drugs. The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that include uniporters, symporters, and antiporters. Members of this family are found in all living organisms and are highly represented in bacteria. MFS members are capable of transporting various substrates such as sugars, polyols, drugs, neurotransmitters, amino acids, peptides, and inorganic anions, although most members are substrate-specific. MFS have provided important insight into the mechanism underlying multidrug transport. MFSD1 is still poorly understood.
REFERENCES: 1) Fluman N and Bibi E. Bacterial multidrug transport through the lens of the major facilitator superfamily. Biochim. Biophys. Acta.2009; 1794:738-47.
2) Law CJ, Maloney PC, and Wang DN. Ins and outs of major facilitator superfamily antiporters. Annu. Rev. Microbiol.2008; 62:289-305.
3) Saidijam M, Benedetti G, Ren Q, et al. Microbial drug efflux proteins of the major facilitator superfamily. Curr. Drug Targets2006; 7:793-811.

For Research Use Only