Datasheet

MettL7A Antibody
CATALOG NUMBER: 4879

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:MettL7A antibody can be used for detection of MettL7A by Western blot at 2 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1288 - A20 Cell Lysate
SPECIFICITY:At least two isoforms of MettL7A are known to exist. This MettL7A antibody is predicted to not cross-react with MettL7B.
IMMUNOGEN:MettL7A antibody was raised against a 12 amino acid synthetic peptide near the carboxy terminus of human MettL7A.

The immunogen is located within the last 50 amino acids of MettL7A.
HOST SPECIES:Rabbit

Properties

PURIFICATION:MettL7A Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:MettL7A Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:MettL7A antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:MettL7A Antibody: AAM-B, Methyltransferase-like protein 7A, Protein AAM-B
ACCESSION NO.:NP_054752
PROTEIN GI NO.:89145417
OFFICIAL SYMBOL:METTL7A
GENE ID:25840

Background

BACKGROUND:MettL7A Antibody: MettL7A belongs to the methyltransferase superfamily. It is a probable methyltransferase. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a donor to an acceptor. Often methylation occurs on nucleic bases in DNA or amino acids in protein structures. DNA methylation is often utilized to silence and regulate genes without changing the original DNA sequence. DNA methylation may be necessary for normal growth from embryonic stages in mammals. When mutant embryonic stem cells lacking the murine DNA methyltransferase gene were introduced to a germline of mice they caused a recessive lethal phenotype. Methylation may also be linked to cancer development as methylation of tumor suppressor genes promotes tumorgenesis and metastasis.
REFERENCES: 1) Clark HF, Gurney AL, Abaya E, et al. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res.2003; 13:2265-70.
2) Li E, Bestor TH, and Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell1992; 69:915-26.
3) Laird PW and Jaenisch R. DNA Methylation and Cancer. Human Molecular Genetics1994; 3:1487-95.

For Research Use Only