Datasheet

MATN2 Antibody
CATALOG NUMBER: 5105

Availability: In stock

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:MATN2 antibody can be used for detection of MATN2 by Western blot at 1 - 2 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1282 - 3T3 (NIH) Cell Lysate
PREDICTED MOLECULAR WEIGHT:Predicted: 102 kDa

Observed: 105 kDa
IMMUNOGEN:MATN2 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human MATN2.

The immunogen is located within amino acids 820 - 870 of MATN2.
HOST SPECIES:Rabbit

Properties

PURIFICATION:MATN2 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:MATN2 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:MATN2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:MATN2 Antibody: Matrilin-2
ACCESSION NO.:NP_085072
PROTEIN GI NO.:62548862
OFFICIAL SYMBOL:MATN2
GENE ID:4147

Background

BACKGROUND:MATN2 Antibody: Matrilin (MATNs) are a family of non-collagenous extracellular matrix proteins consisting of four known members that have been proposed to play key roles in the formation of both collagen-dependent and collagen-independent filamentous networks. The matrilin family all share a structure made up of von Willebrand factor A domains, epidermal growth factor-like domains and a coiled coil alpha-helical module. MATN1 and MATN3 are expressed mainly in cartilage, while MATN2 and MATN4 occur in a wide variety of extracellular matrices. The matrilin genes are strictly and differently regulated and their expression may serve as markers for cellular differentiation and diseases such as astrocytoma and liver carcinoma. Recent studies show that MATN2 is a permissive substrate for axonal growth and cell migration, and it is required for successful nerve regeneration.
REFERENCES: 1) Pei M, Luo J, and Chen Q. Enhancing and maintaining chondrogenesis of synovial fibroblasts by cartilage extracellular matrix protein matrilins. Osteoarthritis Cartilage2008; 16:1110-7.
2) Frank S, Schulthess T, Landwehr R, et al. Characterization of the Matrilin Coiled-coil Domains Reveals Seven Novel Isoforms. J. Biol. Chem.2002; 277:19071-9.
3) Deak F, Wagener R, Kiss I, et al. The matrilins: a novel family of oligomeric extracellular matrix proteins. Matrix Biol.1999; 18:55-64.
4) Szabo E, Korpos E, Batmunkh E, et al. Expression of matrilin-2 in liver cirrhosis and hepatocellular carcinoma. Pathol. Oncol. Res.2008; 14:15-22.

For Research Use Only