MAP2K7 (phospho Thr275) Antibody Cat. No.: 79-856

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
IMMUNOGEN: MAP2K7 (phospho Thr275) antibody was raised against a peptide sequence around phosphorylation site of threonine 275 (A-K-T (p)-R-S) derived from Human MAP2K7.
TESTED APPLICATIONS: WB
APPLICATIONS: Western Blot: 1:500~1:1000
SPECIFICITY: The antibody detects endogenous levels of MAP2K7 only when phosphorylated at threonine 275.
PREDICTED MOLECULAR WEIGHT: 43 kDa

psi-iconProperties
PURIFICATION:Antibodies were purified by affinity-chromatography using epitope-specific peptide.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:Store antibody at -20˚C for up to one year.

psi-iconAdditional Info
OFFICIAL SYMBOL:MAP2K7
ALTERNATE NAMES:PRKMK7, JNKK2, MKK7, MAP2K7, MP2K7
ACCESSION NO.:NP_660186.1
PROTEIN GI NO.:21735544
GENE ID:5609
psi-iconBackground and References
BACKGROUND:The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.
REFERENCES:1) Wu Z.,Mol. Cell. Biol. 17:7407-7416(1997).
2) Lu X.,J. Biol. Chem. 272:24751-24754(1997).
3) The MGC Project Team;Genome Res. 14:2121-2127(2004).

ANTIBODIES FOR RESEARCH USE ONLY.

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