M-CSF R Recombinant Protein Cat. No.: 96-811

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psi-iconSpecifications
SPECIES:Cynomolgus monkey
SOURCE SPECIES:HEK293 cells
SEQUENCE:Ile 99 - Pro 596
FUSION TAG:Fc Tag
TESTED APPLICATIONS:WB
APPLICATIONS:This recombinant protein can be used for WB. For research use only.
psi-iconProperties
PURITY:>95% as determined by SDS-PAGE.

Endotoxin level is less than 1.0 EU per ug by the LAL method.
PREDICTED MOLECULAR WEIGHT:81.9 kDa
PHYSICAL STATE:Lyophilized
BUFFER:Tris with Glycine, Arginine and NaCl, pH7.5
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:CSF1R,C-FMS,CD115,CSFR,FIM2,FMS,M-CSFR
ACCESSION NO.:G7P8P1
OFFICIAL SYMBOL:M-CSF R
psi-iconBackground and References
BACKGROUND:Colony stimulating factor 1 receptor (CSF1R) is also known as macrophage colony-stimulating factor receptor (M-CSFR), CD115 Cluster of Differentiation 115 (CD115), C-FMS, CSFR, FIM2, FMS, and is a member of the typeⅢ subfamily of receptor tyrosine kinases (RTKs). CSF1R is a receptor for a cytokine called colony stimulating factor 1, The protein encoded by the CSFR1 gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSFR1 through a process of oligomerization and transphosphorylation . Mutations in CSF1R are associated with chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. Increased levels of CSF1R1 are found in microglia in Alzheimer's disease and after brain injuries. The increased receptor expression causes microglia to become more active. Both CSF1R, and its ligand colony stimulating factor 1 play an important role in the development of the mammary gland and may be involved in the process of mammary gland carcinogenesis.
REFERENCES:1) Ridge, et al., 1990, Proceedings of the National Academy of Sciences 87 (4): 1377–80.
2) Mitrasinovic, O. M., 2005, Journal of Neuroscience 25 (17): 4442–51.
3) Tamimi, R. M., 2008, Cancer Research 68 (1): 18–21.
4) Pollard, J. W., 1994, Proceedings of the National Academy of Sciences 91 (20): 9312–6.

FOR RESEARCH USE ONLY.

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