LZTR2 Antibody Cat. No.: 5623

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
HOMOLOGY: Predicted species reactivity based on immunogen sequence: Bovine: (100%), Rabbit: (94%)
IMMUNOGEN: LZTR2 antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human LZTR2.

The immunogen is located within the last 50 amino acids of LZTR2.
TESTED APPLICATIONS: ELISA, IF, IHC-P, WB
APPLICATIONS: LZTR2 antibody can be used for detection of LZTR2 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
POSITIVE CONTROL:1) Cat. No. 1405 - Mouse Kidney Tissue Lysate

psi-iconProperties
PURIFICATION:LZTR2 Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:LZTR2 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:LZTR2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:SEC16B
ALTERNATE NAMES:LZTR2 Antibody: RGPR, LZTR2, SEC16S, PGPR-p117, KIAA1928, RGPR, Protein transport protein Sec16B, Leucine zipper transcription regulator 2, RGPR-p117
ACCESSION NO.:NP_149118
PROTEIN GI NO.:116235480
GENE ID:89866
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:LZTR2 Antibody: LZTR2, also known as RGPR-p117, is a member of the BTB-kelch superfamily and was initially described as a nuclear factor I (NFI) binding protein and transcriptional regulator of the regucalcin gene. LZTR2 is cytoplasmically localized but is thought to translocate to the nucleus, a process mediated by protein kinase C signaling following hormonal stimulation. Recent evidence has suggested that there is a strong correlation of single nucleotide polymorphisms of LZTR2 with obesity in the Japanese population similar to that seen with the TMEM18 gene and the GNPDA2, BDNF, FAIM2, and MC4R genes with obesity in Caucasian populations, suggesting LZTR2 may play a role in metabolism and obesity risk.
REFERENCES:1) Misawa H and Yamaguchi M. Molecular cloning and sequencing of the cDNA coding for a novel regucalcin gene promoter region-related protein in rat, mouse and human liver. Int. J. Mol. Med.2001; 8:513-20.
2) Yamaguchi M. Novel protein RGPR-p117: its role as the regucalcin gene transcription factor. Mol. Cell. Biochem.2009; 327:53-63.
3) Hotta K, Nakamura M, Nakamura T, et al. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. J. Hum. Genet.2009; 54:727-31.

ANTIBODIES FOR RESEARCH USE ONLY.

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