Datasheet

LZTR1 Antibody
CATALOG NUMBER: 5621

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
TESTED APPLICATIONS:ELISA, IHC-P, WB
APPLICATIONS:LZTR1 antibody can be used for detection of LZTR1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1301 - Human Heart Tissue Lysate
IMMUNOGEN:LZTR1 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human LZTR1.

The immunogen is located within amino acids 130 - 180 of LZTR1.
HOST SPECIES:Rabbit

Properties

PURIFICATION:LZTR1 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:LZTR1 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:LZTR1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:LZTR1 Antibody: BTBD29, LZTR-1, SWNTS2, TCFL2, Leucine-zipper-like transcriptional regulator 1
ACCESSION NO.:CAJ86451
PROTEIN GI NO.:90403050
OFFICIAL SYMBOL:LZTR1
GENE ID:8216

Background

BACKGROUND:LZTR1 Antibody: LZTR1, a member of the BTB-kelch superfamily, was initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Golgi complex. Deletion of this gene may be associated with DiGeorge syndrome, a developmental field defect involving the third and fourth pharyngeal pouches, causing the absence of thymus and parathyroid glands, congenital cardiac abnormalities and facial dysmorphism. LZTR1 is tyrosine phosphorylated and subsequently degraded upon induction of apoptosis.
REFERENCES: 1) Kurahashi H, Akagi K, Inazawa J, et al. Isolation and characterization of a novel gene deleted in DiGeorge syndrome. Hum. Mol. Genet.1995; 4:541-9.
2) Nacak TG, Leptien K, Fellner D, et al. The BTB-kelch protein LZTR-1 is a novel Golgi protein that is degraded upon induction of apoptosis. J. Biol. Chem.2006; 281:5065-71.

For Research Use Only