Datasheet

LYRM2 Antibody
CATALOG NUMBER: 5661

Availability: In stock

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
HOMOLOGY:Predicted species reactivity based on immunogen sequence: Bovine: (94%)
TESTED APPLICATIONS:ELISA, ICC, IF, WB
APPLICATIONS:LYRM2 antibody can be used for detection of LYRM2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1203 - A549 Cell Lysate
 2) Cat. No. 17-003 - A549 Cell Slide
IMMUNOGEN:LYRM2 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human LYRM2.

The immunogen is located within the last 50 amino acids of LYRM2.
HOST SPECIES:Rabbit

Properties

PURIFICATION:LYRM2 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:LYRM2 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:LYRM2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:LYRM2 Antibody: DJ122O8.2, LYR motif-containing protein 2
ACCESSION NO.:NP_065199
PROTEIN GI NO.:10092689
OFFICIAL SYMBOL:LYRM2
GENE ID:57226

Background

BACKGROUND:LYRM2 Antibody: The Lyr motif found in the LYR-motif containing protein family is similar to that found in the sacchromyces cerevisiae protein ISD11, an iron-sulfur protein in the mitochondria that is thought to play a role in iron homeostasis. No known function has been assigned to LYRM2, although LYRM1 is thought to be involved in preadipocyte progression and LYRM3 has been suggested to be a candidate gene for the branchio-oto-renal (BOR) syndrome.
REFERENCES: 1) Shi Y, Ghosh MC, Tong WH, et al. Human ISD11 is essential for both iron-sulfur cluster assembly and maintenance of normal cellular iron homeostasis. Hum. Mol. Genet.2009; 18:3014-25.
2) Qiu J, Gao CL, Zhang M, et al. LYRM1, a novel gene promotes proliferation and inhibits apoptosis of preadipocytes. Eur. J. Endocrinol.2009; 160:177-84.
3) Lin X, Wells DE, Kimberling WJ, et al. Human NDUFB9 gene: genomic organization and a possible candidate gene associated with deafness disorder mapped to chromosome 8q1 Hum. Heredity1999; 49:75-80.

For Research Use Only