LYRM1 Antibody Cat. No.: 5659

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
IMMUNOGEN: LYRM1 antibody was raised against a 17 amino acid synthetic peptide near the center of human LYRM1.

The immunogen is located within the first 50 amino acids of LYRM1.
TESTED APPLICATIONS: ELISA, IF, IHC-P, WB
APPLICATIONS: LYRM1 antibody can be used for detection of LYRM1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
POSITIVE CONTROL:1) Cat. No. 1304 - Human Liver Tissue Lysate

psi-iconProperties
PURIFICATION:LYRM1 Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:LYRM1 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:LYRM1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:LYRM1
ALTERNATE NAMES:LYRM1 Antibody: A211C6.1, LYR motif-containing protein 1
ACCESSION NO.:EAW66844
PROTEIN GI NO.:119587248
GENE ID:57149
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:LYRM1 Antibody: LYRM1 was one of many genes identified through a suppression subtractive hybridization comparing their expression in omental adipose tissue of obese patients compared to non-obese individuals. Further study confirms that both mRNA and protein levels of LYRM1 are higher in obese individuals. LYRM1 is widely expressed, with highest levels occurring in adipose and liver tissues. It is thought that LYRM1 promotes preadipocyte proliferation and can inhibit apoptosis of preadipocytes. Ectopic LYRM1 expression did not significantly affect adipogenesis, suggesting that LYRM1 can influence adipose tissue homeostasis by modulating the size of the preadipocyte pool.
REFERENCES:1) Qiu J, Ni YH, Gong HX, et al. Identification of differentially expressed genes in omental adipose tissues of obese patients by suppression subtractive hybridization. Biochem. Biophys. Res. Comm.2007; 352:469-78.
2) Qiu J, Gao CL, Zhang M, et al. LYRM1, a novel gene promotes proliferation and inhibits apoptosis of preadipocytes. Eur. J. Endocrinol.2009; 160:177-84.

ANTIBODIES FOR RESEARCH USE ONLY.

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