LY6K Antibody Cat. No.: 6437

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
IMMUNOGEN: LY6K antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human LY6K.

The immunogen is located within the first 50 amino acids of LY6K.
TESTED APPLICATIONS: ELISA, WB
APPLICATIONS: LY6K antibody can be used for detection of LY6K by Western blot at 1 - 2 μg/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
SPECIFICITY: Multiple isoforms of LY6K are known to exist.
POSITIVE CONTROL:1) Cat. No. 1201 - HeLa Cell Lysate

psi-iconProperties
PURIFICATION:LY6K Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:LY6K Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:LY6K antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:LY6K
ALTERNATE NAMES:LY6K Antibody: CT97, ly-6K, HSJ001348, CO16, Lymphocyte antigen 6K, Ly-6K
ACCESSION NO.:EAW82311
PROTEIN GI NO.:237820711
GENE ID:54742
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:LY6K Antibody: The lymphocyte antigen 6 complex locus K (LY6K), a member of cancer-testis antigen was initially identified as a molecular marker for head-and-neck squamous cell carcinoma as well a breast cancer. LY6K is a GPI-anchored membrane protein that is specifically associated with germ cell marker TEX101 and is strongly observed in testis, but only weakly in other tissues. LY6K mRNA was found to be upregulated in numerous bladder cancers due to gene amplification. Furthermore, knockdown experiments using LY6K siRNA reduced cell growth, migration and invasion in bladder carcinoma cell lines, suggesting that LY6K contributes to bladder cancer development.
REFERENCES:1) de Nooij-van Dalen AG, van Dongen GA, Smeets SJ, et al. Characterization of the human Ly-6 antigens, the newly annotated member Ly-6K included, as molecular markers for head-and-neck squamous cell carcinoma. Int. J. Cancer 2003; 103:768-74.
2) Lee JW, Lee YS, Yoo KH, et al. LY-6K gene: a novel molecular marker for human breast cancer. Oncol. Rep. 2006; 16:1211-4.
3) Yoshitake H, Tsukamoto H, Maruyama-Fukushima M, et al. TEX101, a germ cell-marker glycoprotein, is associated with lymphocyte antigen 6 complex locus K within the mouse testis. Biochem. Biophys. Res. Commun. 2008; 372:277-82.
4) Maruyama M, Yoshitake H, Tsukamoto H, et al. Molecular expression of Ly6k, a putative glycosylphosphatidyl-inositol-anchored membrane protein on the mouse testicular germ cells. Biochem. Biophys. Res. Commun. 2010; 402:75-81.

ANTIBODIES FOR RESEARCH USE ONLY.

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