Ly-49C/F/H/I Antibody [14B11] (Biotin) Cat. No.: 98-936

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psi-iconSpecifications
HOST SPECIES:Hamster
SPECIES REACTIVITY: Mouse
IMMUNOGEN: IL-2 activated natural killed (A-LAK) cells from C57BL/6 mice
TESTED APPLICATIONS: Flow
APPLICATIONS: Ly-49C/F/H/I Antibody [14B11] for use in flow cytometry assays.
SPECIFICITY: Ly-49C/F/H/I

psi-iconProperties
CLONALITY:Monoclonal
ISOTYPE:IgG
CONJUGATE:Biotin
PHYSICAL STATE:Liquid
BUFFER:Supplied in PBS/NaN3
CONCENTRATION:0.5 mg/mL
STORAGE CONDITIONS:Store vial at 2-8˚C

psi-iconAdditional Info
OFFICIAL SYMBOL:Klra3
ALTERNATE NAMES:Ly-49
ACCESSION NO.:Q64329
GENE ID:16634/16637/16639/16640
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:The monoclonal antibody 14B11 reacts with murine Ly49C, Ly49F, Ly49H, and Ly49I, members of the lectin-like homodimeric Ly49 family of cell surface receptors. Mouse Ly49 receptors exhibit allelic specificity for MHC class I Ia molecules and are thought to serve to prevent natural killer (NK) cells from attacking normal cells while allowing them to attack infected or transformed cells in which class I molecules have been downregulated. These inhibitory receptors are also expressed on a subpopulation of mouse CD8+ T cells. The 14B11 antibody stains ~90% of NK1.1+CD3- splenocytes and ~6% of CD8+ spleen cells from C57BL/6 mice. The antibody also stains 30-80% of NK1.1+CD3- splenocytes in other mouse strains tested (BALB/c, C3H, 129, SJL, AKR/J).

ANTIBODIES FOR RESEARCH USE ONLY.

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