| HOST SPECIES: | Rabbit |
| SPECIES REACTIVITY: | Human, Mouse, Rat |
| IMMUNOGEN: | LXR-B antibody was raised against a 14 amino acid synthetic peptide from near the amino terminus human LXR-B. The immunogen is located within the first 50 amino acids of LXR-B. |
| TESTED APPLICATIONS: | ELISA, WB |
| APPLICATIONS: | LXR-B antibody can be used for detection of LXR-B by Western blot at 1 - 2 μg/mL. Antibody validated: Western Blot in human samples. All other applications and species not yet tested. |
| POSITIVE CONTROL: | 1) Cat. No. 1302 - Human Lung Tissue Lysate |
Specifications| PURIFICATION: | LXR-B Antibody is affinity chromatography purified via peptide column. |
| CLONALITY: | Polyclonal |
| ISOTYPE: | IgG |
| CONJUGATE: | Unconjugated |
| PHYSICAL STATE: | Liquid |
| BUFFER: | LXR-B Antibody is supplied in PBS containing 0.02% sodium azide. |
| CONCENTRATION: | 1 mg/mL |
| STORAGE CONDITIONS: | LXR-B antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| OFFICIAL SYMBOL: | NR1H2 |
| ALTERNATE NAMES: | LXR-B Antibody: NER, UNR, LXRB, LXR-b, NER-I, RIP15, NER, Oxysterols receptor LXR-beta, Liver X receptor beta |
| ACCESSION NO.: | P55055 |
| PROTEIN GI NO.: | 1709254 |
| GENE ID: | 7376 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
| BACKGROUND: | LXR-B Antibody: LXR-B belongs to the Liver X Receptor family that encodes highly homologous transcription factors. Like the highly homologous LXR-A, LXR-B forms heterodimers with the retinoic acid receptor RXRalpha, which function as sensors for cellular oxysterols which when activated, increase the expression of genes that control sterol and fatty acid metabolism and homeostasis. Recent experiments have indicated that the LXRs can also modulate both innate and adaptive immune responses. Other studies suggest that genetic variability at the LXR-B gene locus may be a risk factor for Alzheimer's disease. One hypothesis postulates that LXR may be upstream of ApoE and potentiates the risk associated effects of the epsilon3 allele. |
| REFERENCES: | 1) Willy PJ, Umesono K, Ong ES, et al. LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev.1995; 9:1033-45. | 2) Edwards PA, Kennedy MA, and Mak PA. LXRs; Oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis. Vasc. Pharmacol.2002; 38:249-56. | 3) Bensinger SJ and Tontonoz P. Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature2008; 454:470-7. | 4) Adighibe O, Arepalli S, Duckworth J, et al. Genetic variability at the LXR gene (NR1H2) may contribute to the risk of Alzheimer’s disease. Nerobiol. Aging2006; 27:1431-4. |
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