Datasheet

LRRC26 Antibody
CATALOG NUMBER: 7539

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human
TESTED APPLICATIONS:ELISA, IF, IHC-P, WB
APPLICATIONS:LRRC26 antibody can be used for detection of LRRC26 by Western blot at 0.5 - 1 μg/ml. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1312 - Human Prostate Tissue Lysate
 2) Cat. No. 1205 - Jurkat Cell Lysate
PREDICTED MOLECULAR WEIGHT:Predicted: 37 kDa

Observed: 48 kDa
SPECIFICITY:LRRC26 antibody is human specific.
IMMUNOGEN:LRRC26 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human LRRC26.

The immunogen is located within the last 50 amino acids of LRRC26.
HOST SPECIES:Rabbit

Properties

PURIFICATION:LRRC26 antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:LRRC26 antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:LRRC26 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:LRRC26 Antibody: CAPC, bA350O14.10, CAPC, Leucine-rich repeat-containing protein 26, BK channel auxiliary gamma subunit LRRC26
ACCESSION NO.:NP_001013675
PROTEIN GI NO.:61966761
OFFICIAL SYMBOL:LRRC26
GENE ID:389816

Background

BACKGROUND:The LRRC26 protein was initially identified as a cytokeratin-associated protein whose expression was elevated in multiple cancer cell lines and cancer specimens as well in normal prostate and salivary gland tissues (1). LRRC26 was later found to negatively regulate the NF-kappaB activation and suppresses tumor growth and metastasis (2). LRRC26 can also act to selectively alter the efficacy of large conductance calcium-activated K (BK) channels (3).
REFERENCES: 1) Egland KA, Liu XF, Squires S, et al. High expression of a cytokeratin-associated protein in many cancers. Proc. Natl. Acad. Sci. USA 2006; 103:5929-34.
2) Liu XF, Xiang L, Zhang Y, et al. CAPC negatively regulates NF-?B activation and suppresses tumor growth and metastasis. Oncogene 2012; 31:1673-82.
3) Almassy J and Begenisich T. The LRRC26 protein selectively alters the efficacy of BK channel activators. Mol. Pharmacol. 2012; 81:21-30.

For Research Use Only