Lipoma Preferred Partner Antibody Cat. No.: 36-343

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Pig, Rat
IMMUNOGEN: Recombinant human lipoma preferred partner (LPP) (aa 1-109).
TESTED APPLICATIONS: ICC, IP, WB
APPLICATIONS: Immunocytochemistry: (1:500). Immunohistochemistry: (1:500). Western Blot: (1:1,000) . Optimal conditions must be determined individually for each application.
SPECIFICITY: Recognizes human, rat and pig LPP.

psi-iconProperties
PURIFICATION:Antigen affinity purified.
CLONALITY:Polyclonal
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Liquid. In PBS containing 0.01% sodium azide.
CONCENTRATION:500 ug/ml
STORAGE CONDITIONS:Stable for at least 1 year after receipt when stored at -20˚C.

psi-iconAdditional Info
OFFICIAL SYMBOL:LPP
ALTERNATE NAMES:LPP; LIM Domain-containing Preferred Translocation Partner in Lipoma
ACCESSION NO.:NP_001161143.1
PROTEIN GI NO.:264681524
GENE ID:4026
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Lipoma preferred partner (LPP) is encoded by the preferred fusion partner gene of the high mobility group protein HMGI-C. LPP is frequently affected by chromosomal translocations in a major group of soft tissue lipomas, as well as in a parosteal lipoma and in pulmonary chondroid hamartomas. The resulting fusion proteins comprise three DNA binding domains of HMGI-C fused to two or three C-terminal LIM domains of LPP and a reciprocal product, respectively. Expression of a HMGI-C/LPP fusion protein causes malignant transformation of fibroblasts. Similar to its relatives zyxin and TRIP (thyroid receptor interacting protein 6) / ZRP-1 (zyxin-related protein 1), LPP consists of a N-terminal proline-rich domain followed by three C-terminal LIM domains (double zinc finger structures that are involved in protein-protein interactions). Like the cytoskeletal protein zyxin, LPP localizes to focal adhesions and cell-cell adherens junctions. LPP harbors a nuclear export signal and displays transcriptional activation capacity.

ANTIBODIES FOR RESEARCH USE ONLY.

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