This recombinant protein can be used for E, WB. For research use only.
BIOLOGICAL ACTIVITY:
Measured by its binding ability in a functional ELISA. Immobilized Human ANGPTL7, His Tag at 5 ug/mL (100 uL/well) can bind Cynomolgus LILRB4, Fc Tag with a linear range of 10-156 ng/mL (QC tested).
Properties
PURITY:
>85% as determined by SDS-PAGE.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
PREDICTED MOLECULAR WEIGHT:
52.7 kDa
PHYSICAL STATE:
Lyophilized
BUFFER:
Tris with Glycine, Arginine and NaCl, pH7.5
STORAGE CONDITIONS:
Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
Additional Info
ALTERNATE NAMES:
LILRB4,ILT3,LIR5,CD85K,HM18
ACCESSION NO.:
XP_015297198.1
OFFICIAL SYMBOL:
LILRB4
GENE ID:
107128256
Background and References
BACKGROUND:
Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
REFERENCES:
1) Cella M., et al., 1997, J. Exp. Med. 185:1743-1751.
2) Chang C.C., et al., 2002, Nat. Immunol. 3:237-243.
Specifications
