LAMTOR2 Antibody Cat. No.: 7711

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
HOMOLOGY: Predicted species reactivity based on immunogen sequence: Bovine: (100%)
IMMUNOGEN: LAMTOR2 antibody was raised against an 18 amino acid peptide near the center of human LAMTOR2.

The immunogen is located within amino acids 40 - 90 of LAMTOR2.
TESTED APPLICATIONS: ELISA, IF, IHC-P, WB
APPLICATIONS: LAMTOR2 antibody can be used for detection of LAMTOR2 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
SPECIFICITY: LAMTOR2 antibody is human, mouse and rat reactive. At least two isoforms of LAMTOR2 are known to exist; this antibody will detect both isoforms. LAMTOR2 antibody is predicted to not cross-react with other LAMTOR family proteins.
POSITIVE CONTROL:1) Cat. No. 1211 - HepG2 Cell Lysate
 2) Cat. No. 10-901 - Human Spleen Tissue Slide
PREDICTED MOLECULAR WEIGHT: Predicted: 14 kDa

Observed: 16 kDa

psi-iconProperties
PURIFICATION:LAMTOR2 antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:LAMTOR2 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:LAMTOR2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

psi-iconAdditional Info
OFFICIAL SYMBOL:LAMTOR2
ALTERNATE NAMES:LAMTOR2 Antibody: p14, ENDAP, ROBLD3, HSPC003, MAPBPIP, MAPKSP1AP, Ragulator2, Ragulator complex protein LAMTOR2, Endosomal adaptor protein p14, MAPBP-interacting protein
ACCESSION NO.:NP_054736
PROTEIN GI NO.:7661728
GENE ID:28956
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:The late endosomal/lysosomal adaptor MAPK and MTOR activator 2 (LAMTOR2) protein belongs to the LAMTOR family of proteins, and together with LAMTOR3 and the MAPK1 and ERK kinase 1 (MEK1) localizes to late endosomes where it is required for the efficient activation of ERK signaling (1,2). This complex is involved in the regulation of late endosomal traffic and cellular proliferation (3) and plays a role in cellular host defense against Salmonella infection (4).
REFERENCES:1) Wunderlich W, Fialka I, Teis D, et al. A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold MP1 on a late endosomal/lysosomal compartment. J. Cell Biol. 2001; 152:765-76.
2) Teis D, Wunderlich W, and Huber LA. Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction. Dev. Cell 2002; 3:803-14.
3) Teis D, Taub N, Kurzbauer R, et al. p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis. J. Cell Biol. 2006; 175:861-8.
4) Taub N, Nairz M, Hilber D, et al. The late endosomal adaptor p14 is a macrophage host-defense factor against Salmonella infection. J. Cell Sci. 2012; 125:2698-708.

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