LAIR1 / CD305 Recombinant Protein Cat. No.: 11-513

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psi-iconSpecifications
SPECIES:Mouse
SOURCE SPECIES:HEK293 cells
SEQUENCE:Gln 22 - Tyr 141
FUSION TAG:Mouse IgG Fc Tag
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.6 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
psi-iconProperties
PURITY:>95% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:40.6 kDa
PHYSICAL STATE:Lyophilized
BUFFER:50 mM Tris, 100 mM Glycine, pH7.5
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:LAIR1,CD305
ACCESSION NO.: NP_001106945.1
OFFICIAL SYMBOL:Lair1
GENE ID:52855
psi-iconBackground and References
BACKGROUND:Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.
REFERENCES:1) Pioli C, et all., 2000, J Immunol. 15;165(10):5530-6.
2) Brondijk TH, et all., 2010, Blood. 18;115(7):1364-73
3) Meyaard L, et all., 1997, Immunity. Aug;7(2):283-90.

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