LAG3 Detection Set (Risk Free) Cat. No.: RF16080

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psi-iconSpecifications
SPECIES REACTIVITY:Human
TESTED APPLICATIONS:Flow, IF, IHC-P
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
IMMUNOGEN:LAG3 antibodies were raised against the extracellular domain of human LAG3.
HOST SPECIES:Mouse
psi-iconSet Contents
Catalog Number RF16082Catalog number RF16082 — LAG3 Antibody [2G8]
Catalog Number RF16083Catalog number RF16083 — LAG3 Antibody [7A7]
Catalog Number RF16084Catalog number RF16084 — LAG3 Antibody [9F9]
Catalog Number RF16086Catalog number RF16086 — LAG3 Antibody [6B12]
Catalog Number RF16087Catalog number RF16087 — LAG3 Antibody [6D1]
Catalog Number RF16088Catalog number RF16088 — LAG3 Antibody [5F11]
Catalog Number RF16089Catalog number RF16089 — LAG3 Antibody [1G4]
psi-iconProperties
PHYSICAL STATE:Liquid
BUFFER:PBS containing 0.02% sodium azide.
CONCENTRATION:Antibody 1 mg/mL
STORAGE CONDITIONS:Antibodies can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Monoclonal
ISOTYPE:IgG1, IgG2a
CONJUGATE:Unconjugated
psi-iconAdditional Info
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground
BACKGROUND:The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2). It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4). LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy. ProSci's Risk-FreeTM antibodies are mouse monoclonal antibodies made to improve in vivo studies. Unlike antibodies developed using proteins made in yeast or bacteria, Risk-FreeTM antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein. Validated for flow cytometry and ELISA Rigorously tested for the following applications: Immunoblot Immunohistochemistry Immunocytochemistry Immunofluorescence Multiple antibodies per target allowing the user to choose the best antibody for their application Available individually or as a set Risk-FreeTM means they are guaranteed to work for their approved applications

DETECTION-SETS FOR RESEARCH USE ONLY.

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