LAG3 Detection Set Cat. No.: SD8700

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psi-iconSpecifications
SPECIES REACTIVITY:Human
TESTED APPLICATIONS:ELISA, Flow, ICC, IF, IHC
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
IMMUNOGEN:LAG3 antibodies were raised against a recombinant protein corresponding to amino acids 23-434 of human LAG3.
HOST SPECIES:Llama
psi-iconSet Contents
Catalog Number SD8837Catalog number SD8837 — LAG-3 Antibody [2A11]
Catalog Number SD8839Catalog number SD8839 — LAG-3 Antibody [1A6]
Catalog Number SD8841Catalog number SD8841 — LAG-3 Antibody [2B11]
Catalog Number SD8842Catalog number SD8842 — LAG-3 Antibody [1C6]
Catalog Number SD8843Catalog number SD8843 — LAG-3 Antibody [1A8]
psi-iconProperties
PHYSICAL STATE:Liquid
BUFFER:LAG3 Antibodies are supplied in PBS.
CONCENTRATION:Antibody 1 mg/mL
STORAGE CONDITIONS:LAG3 antibodies should be stored in working aliquots at -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Monoclonal
ISOTYPE:sdab
CONJUGATE:Unconjugated
psi-iconAdditional Info
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground
BACKGROUND:The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2). It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4). LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions. Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy.

DETECTION-SETS FOR RESEARCH USE ONLY.

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