| SPECIES: | Human, Mouse |
| SOURCE SPECIES: | CHO cells |
| SEQUENCE: | The sequence coding for the 4 extracellular Ig-like domains of mouse LAG-3 (D1-D4) is fused to the Fc portion of mouse IgG2a (hinge-CH2-CH3). |
| FUSION TAG: | Fc Tag |
| TESTED APPLICATIONS: | |
| APPLICATIONS: | This recombinant proteins is for research use only. |
| BIOLOGICAL ACTIVITY: | Induces maturation of mouse dendritic cells in vitro. Induces CD4 and CD8 antigen-specific T cells responses when coinjected s.c. in mice, together with the antigen. |
Specifications| PURITY: | >95% (SDS-PAGE). Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza). |
| PHYSICAL STATE: | Liquid |
| BUFFER: | In PBS. |
| CONCENTRATION: | 0.5 mg/ml |
| STORAGE CONDITIONS: | Stable for at least 6 months after receipt when stored at +4˚C. |
| ALTERNATE NAMES: | Lymphocyte Activation Gene-3, FDC Protein, CD223 |
| ACCESSION NO.: | Q61790 |
| PROTEIN GI NO.: | 2497295 |
| OFFICIAL SYMBOL: | LAG3 |
| GENE ID: | 16768 |
| BACKGROUND: | Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4. |
FOR RESEARCH USE ONLY.
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