LAG-3 Recombinant Protein Cat. No.: 90-246

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psi-iconSpecifications
SPECIES:Human, Mouse
SOURCE SPECIES:CHO cells
SEQUENCE:The sequence coding for the 4 extracellular Ig-like domains of mouse LAG-3 (D1-D4) is fused to the Fc portion of mouse IgG2a (hinge-CH2-CH3).
FUSION TAG:Fc Tag
TESTED APPLICATIONS:
APPLICATIONS:This recombinant proteins is for research use only.
BIOLOGICAL ACTIVITY: Induces maturation of mouse dendritic cells in vitro. Induces CD4 and CD8 antigen-specific T cells responses when coinjected s.c. in mice, together with the antigen.
psi-iconProperties
PURITY:>95% (SDS-PAGE).

Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza).
PHYSICAL STATE:Liquid
BUFFER:In PBS.
CONCENTRATION:0.5 mg/ml
STORAGE CONDITIONS:Stable for at least 6 months after receipt when stored at +4˚C.
psi-iconAdditional Info
ALTERNATE NAMES:Lymphocyte Activation Gene-3, FDC Protein, CD223
ACCESSION NO.:Q61790
PROTEIN GI NO.:2497295
OFFICIAL SYMBOL:LAG3
GENE ID:16768
psi-iconBackground and References
BACKGROUND:Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.

FOR RESEARCH USE ONLY.

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