SPECIES: | Human, Monkey, Mouse |
SOURCE SPECIES: | CHO cells |
SEQUENCE: | The sequence coding for the 4 extracellular Ig-like domains of human LAG-3 (D1-D4) is fused to the Fc portion of human IgG1. |
FUSION TAG: | Fc Tag |
TESTED APPLICATIONS: | |
APPLICATIONS: | This recombinant proteins is for research use only. |
BIOLOGICAL ACTIVITY: | Inhibits binding of MAb to LAG-3 (human) to LAG-3. Induces maturation of human dendritic cells. |
PURITY: | >99% (SDS-PAGE). Endotoxin level is less than 0.1EU/ μg purified protein (LAL test; Lonza). |
PHYSICAL STATE: | Liquid |
BUFFER: | In PBS. |
CONCENTRATION: | 0.5 mg/ml |
STORAGE CONDITIONS: | Stable for at least 6 months after receipt when stored at -20˚C. |
ALTERNATE NAMES: | Lymphocyte Activation Gene-3, FDC Protein, CD223 |
ACCESSION NO.: | P18627 |
PROTEIN GI NO.: | 251757512 |
OFFICIAL SYMBOL: | LAG3 |
GENE ID: | 3902 |
BACKGROUND: | Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4. |
FOR RESEARCH USE ONLY.
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