| SPECIES: | Human, Monkey, Mouse |
| SOURCE SPECIES: | CHO cells |
| SEQUENCE: | The sequence coding for the 4 extracellular Ig-like domains of human LAG-3 (D1-D4) is fused to the Fc portion of human IgG1. |
| FUSION TAG: | Fc Tag |
| TESTED APPLICATIONS: | |
| APPLICATIONS: | This recombinant proteins is for research use only. |
| BIOLOGICAL ACTIVITY: | Inhibits binding of MAb to LAG-3 (human) to LAG-3. Induces maturation of human dendritic cells. |
Specifications| PURITY: | >99% (SDS-PAGE). Endotoxin level is less than 0.1EU/ μg purified protein (LAL test; Lonza). |
| PHYSICAL STATE: | Liquid |
| BUFFER: | In PBS. |
| CONCENTRATION: | 0.5 mg/ml |
| STORAGE CONDITIONS: | Stable for at least 6 months after receipt when stored at -20˚C. |
| ALTERNATE NAMES: | Lymphocyte Activation Gene-3, FDC Protein, CD223 |
| ACCESSION NO.: | P18627 |
| PROTEIN GI NO.: | 251757512 |
| OFFICIAL SYMBOL: | LAG3 |
| GENE ID: | 3902 |
| BACKGROUND: | Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4. |
FOR RESEARCH USE ONLY.
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