KPNA7 Antibody Cat. No.: 5993

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human
IMMUNOGEN: KPNA7 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of human KPNA7.

The immunogen is located within amino acids 40 - 90 of KPNA7.
TESTED APPLICATIONS: ELISA, IHC-P, WB
APPLICATIONS: KPNA7 antibody can be used for detection of KPNA7 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.
SPECIFICITY: KPNA7 antibody is human specific. KPNA7 antibody is predicted to not cross-react with other Importin alpha family members.

psi-iconProperties
PURIFICATION:KPNA7 Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:KPNA7 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:KPNA7 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:KPNA7
ALTERNATE NAMES:KPNA7 Antibody: Importin subunit alpha-8, Karyopherin subunit alpha-7
ACCESSION NO.:NP_001139187
PROTEIN GI NO.:224589129
GENE ID:402569
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:KPNA7 Antibody: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA7 is most closely related to KPNA2, but unlike KPNA2, KPNA7 primarily localizes to the nucleus. It has been suggested that KPNA7 may play a role in the transport of essential nuclear proteins required for early embryogenesis.
REFERENCES:1) Moroianu J. Molecular mechanisms of nuclear protein transport. Crit. Rev. Eukaryot. Gene. Expr. 1997; 7:61-72.
2) Gilchrist D and Rexach M. Molecular basis for the rapid dissociation of nuclear localization signals from karyopherin alpha in the nucleoplasm. J. Biol. Chem. 2003; 278: 51937-49.
3) Tejomurtula J, Lee KB, Tripurani SK, et al. Role of importin alpha8, a new member of the importin alpha family of nuclear transport proteins, in early embryonic development in cattle. Biol. Reprod. 2009; 81:333-42.
4) Kelley JB, Talley AM, Spencer A, et al. Karyopherin a7 (KPNA7), a divergent member of the importin a family of nuclear import receptors. BMC Cell Biol. 2010; 11:63.

ANTIBODIES FOR RESEARCH USE ONLY.

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