Datasheet

KLRA3 Antibody
CATALOG NUMBER: 4993

Availability: In stock

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Mouse, Rat
TESTED APPLICATIONS:ELISA, WB
APPLICATIONS:KLRA3 antibody can be used for detection of KLRA3 by Western blot at 2 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1403 - Mouse Brain Tissue Lysate
SPECIFICITY:This antibody may cross-react with other LY49 receptors.
IMMUNOGEN:KLRA3 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of mouse KLRA3.

The immunogen is located within the last 50 amino acids of KLRA3.
HOST SPECIES:Rabbit

Properties

PURIFICATION:KLRA3 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:KLRA3 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:KLRA3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:KLRA3 Antibody: 5E6, Nk2, Nk-2, Ly49c, Nk2.1, NK-2.1, Ly-49c, Ly49C, Killer cell lectin-like receptor 3, 5E6
ACCESSION NO.:AAI32525
PROTEIN GI NO.:124376782
OFFICIAL SYMBOL:Klra3
GENE ID:16634

Background

BACKGROUND:KLRA3 Antibody: KLRA3 (also known as Ly49C) is a member of the LY49 family of receptors in Natural Killer (NK) cells that bind to major histocompatibility complex (MHC) class 1. These proteins are classified as either activating or inhibitory receptors based on whether they possess an immunoreceptor tyrosine-based inhibitory motif (ITIM) in their cytoplasmic region (for inhibitory receptors), or an immunoreceptor tyrosine-based activation motif (ITAM) that transmits activating signals resulting in phosphorylation of several substrates. KLRA3 is thought to be an inhibitory receptor, recognizing peptide -receptive H-2Kb.
REFERENCES: 1) Gosselin P, Lusignan Y, Brennan J, et al. The NK2.1 receptor is encoded by Ly-49C and its expression is regulated by MHC class I alleles. Int. Immunol.1997; 533-40.
2) Smith HR, Karlhofer FM, and Yokoyama WM. Ly-49 multigene family expressed by IL-2-activated NK cells. J. Immunol.1994; 153:1068-79.
3) Brennan J, Mager D, Jefferies W, et al. Expression of different members of the Ly-49 gene family defines distinct natural killer cell subsets and cell adhesion properties. J. Exp. Med.1994; 180:2287-95.
4) Su R-C, Kung SK, Silver ET, et al. Ly-49CB6 NK inhibitory receptor recognizes peptide-receptive H-2Kb. J. Immunol.1999; 163:5319-30.

For Research Use Only