KCNK13 Antibody Cat. No.: 6423

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Human, Mouse, Rat
IMMUNOGEN: KCNK13 antibody was raised against a 15 amino acid synthetic peptide near the center of human KCNK13.

The immunogen is located within amino acids 150 - 200 of KCNK13.
TESTED APPLICATIONS: ELISA, IF, IHC-P, WB
APPLICATIONS: KCNK13 antibody can be used for detection of KCNK13 by Western blot at 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.

Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
SPECIFICITY: KCNK13 antibody is predicted to not cross-react with other KCNK protein family members.
POSITIVE CONTROL:1) Cat. No. 1463 - Rat Brain Tissue Lysate
 2) Cat. No. 10-301 - Human Brain Tissue Slide

psi-iconProperties
PURIFICATION:KCNK13 Antibody is affinity chromatography purified via peptide column.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:KCNK13 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:KCNK13 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

psi-iconAdditional Info
OFFICIAL SYMBOL:KCNK13
ALTERNATE NAMES:KCNK13 Antibody: THIK1, THIK-1, K2p13.1, Potassium channel subfamily K member 13, Tandem pore domain halothane-inhibited potassium channel 1
ACCESSION NO.:NP_071337
PROTEIN GI NO.:16306555
GENE ID:56659
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:KCNK13 Antibody: The closely related proteins KCNK13 and KCNK12 (also known as THIK1 and 2) are the first two members of a novel two pore-forming P domains K+ channels subfamily. The pore loop domain, a highly conserved region common to all potassium channels, is involved in determining potassium ion selectivity. Members of this family are all characterized by four transmembrane domains and may function to help influence the resting membrane potential of cells. KCNK13 is expressed mainly in the brain, but is also observed in kidneys. KCNK13 has been suggested to be a candidate for the Cs+-permeable K+ channel activated by GABA(B) receptors.
REFERENCES:1) Rajan S, Wischmeyer E, Karschin C, et al. THIK-1 and THIK-2, a novel subfamily of tandem pore domain K+ channels. J. Biol. Chem. 2001; 276:7302-11.
2) Jezzini SH and Moroz LL. Identification and distribution of a twopore domain potassium channel in the CNS of Aplysia californica. Brain Res. Mol. Brain Res. 2004; 127:27-38.
3) Theilig F, Goranova I, Hirsch JR, et al. Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney. Cell Physiol. Biochem. 2008; 21:63-74
4) Ishii H, Nakajo K, Yanagawa Y, et al. Identification and characterization of Cs(+)-permeable K(+) channel current in mouse cerebellar Purkinje cells in lobules 9 and 10 evoked by molecular layer stimulation. Eur. J. Neurosci. 2010; 32:736-48

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