Datasheet

KAT5 Antibody
CATALOG NUMBER: 7339

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human, Mouse, Rat
TESTED APPLICATIONS:ELISA, IF, IHC-P, WB
APPLICATIONS:KAT5 antibody can be used for detection of KAT5 by Western blot at 1 - 2 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1303 - Human Brain Tissue Lysate
PREDICTED MOLECULAR WEIGHT:Predicted: 51, 54, 56, 60 kDa

Observed: 53 kDa
SPECIFICITY:Multiple isoforms of KAT5 are known to exist.
IMMUNOGEN:KAT5 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human KAT5.

The immunogen is located within the last 50 amino acids of KAT5.
HOST SPECIES:Rabbit

Properties

PURIFICATION:KAT5 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:KAT5 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:KAT5 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:KAT5 Antibody: TIP, ESA1, PLIP, TIP60, cPLA2, HTATIP, ZC2HC5, HTATIP1, Histone acetyltransferase KAT5, 60 kDa Tat-interactive protein, Tip60
ACCESSION NO.:NP_874369
PROTEIN GI NO.:36287069
OFFICIAL SYMBOL:KAT5
GENE ID:10524

Background

BACKGROUND:KAT5 Antibody: KAT5 belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and non-histone proteins. KAT5 has been shown to play a role in DNA repair and apoptosis and is thought to play an important role in signal transduction and autophagy.
REFERENCES: 1) Kamine J, Elangovan B, Subramanian T, et al. Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator. Virology 1996; 216:357-66.
2) Kimura A and Horikoshi M. Tip60 acetylates six lysines of a specific class of core histones in vitro. Genes Cells 1998; 3:789-800.
3) Ikura T, Ogryzko VV, Grigoriev M, et al. Involvement of the TIP70 histone acetylase complex in DNA repair and apoptosis. Cell 2000; 102:463-73.
4) Lin SY, Li TY, Liu Q, et al. GSK3-TIP60-ILK1 signaling pathway links growth factor deprivation to autophagy. Science 2012; 336:477-81.

For Research Use Only