| HOST SPECIES: | Rabbit |
| SPECIES REACTIVITY: | Human, Mouse, Rat |
| HOMOLOGY: | Predicted species reactivity based on immunogen sequence: Bovine: (100%) |
| IMMUNOGEN: | Rabbit polyclonal JAKMIP1 antibody was raised against a 16 amino acid peptide near the center of human JAKMIP1. The immunogen is located within amino acids 260 - 310 of JAKMIP1. |
| TESTED APPLICATIONS: | ELISA, WB |
| APPLICATIONS: | JAKMIP1 antibody can be used for detection of JAKMIP1 by Western blot at 1 - 2 μg/mL. Antibody validated: Western Blot in rat samples. All other applications and species not yet tested. |
| SPECIFICITY: | Multiple isoforms of JAKMIP1 are known to exist. JAKMIP1 antibody is predicted to not cross-react with JAKMIP2. |
| POSITIVE CONTROL: | 1) Cat. No. 1463 - Rat Brain Tissue Lysate |
| PREDICTED MOLECULAR WEIGHT: | Predicted: 69 kDa |
Specifications| PURIFICATION: | JAKMIP1 Antibody is affinity chromatography purified via peptide column. |
| CLONALITY: | Polyclonal |
| ISOTYPE: | IgG |
| CONJUGATE: | Unconjugated |
| PHYSICAL STATE: | Liquid |
| BUFFER: | JAKMIP1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| CONCENTRATION: | 1 mg/mL |
| STORAGE CONDITIONS: | JAKMIP1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. |
| OFFICIAL SYMBOL: | JAKMIP1 |
| ALTERNATE NAMES: | JAKMIP1 Antibody: JAMIP1, MARLIN1, Gababrbp, GABABRBP, JAMIP1, Janus kinase and microtubule-interacting protein 1, GABA-B receptor-binding protein, Marlin-1 |
| ACCESSION NO.: | NP_653321 |
| PROTEIN GI NO.: | 21389505 |
| GENE ID: | 152789 |
| USER NOTE: | Optimal dilutions for each application to be determined by the researcher. |
| BACKGROUND: | JAKMIP1 Antibody: JAKMIP1, also known as Marlin-1, is a highly-conserved vertebrate-specific microtubule-associated protein that plays a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements. JAKMIP1 is expressed predominantly in neuronal and lymphoid cells and colocalizes with microtubules. Multiple isoforms of JAKMIP1 are known to exist: isoforms 1 and 5 are also expressed in liver, lung and skeletal muscle, while isoforms 2-4 are specifically expressed in brain and retina. JAKMIP1 participates in polarized secretion in lymphocytes and it has been suggested to be a novel effector memory gene restraining T cell-mediated cytotoxicity. Dysregulation of JAKMIP1 gene expression is associated with genetic conditions linked to autism in humans. |
| REFERENCES: | 1) Costa V, Conte I, Ziviello C, et al. Identification and expression analysis of novel Jakmip1 transcripts. Gene 2007; 402:1-8. | 2) Vidal RL, Fuentes P, Valenzuela JI, et al. RNA interference of Marlin-1/Jakmip1 results in abnormal morphogenesis and migration of cortical pyramidal neurons. Mol. Cell Neurosci. 2012; epub. | 3) Libri V, Schulte D, Van Stijn A et al. Jakmip1 is expressed upon T cell differentiation and has an inhibitory function in cytotoxic T lymphocytes. J. Immunol. 2008; 181:5847-56 | 4) Bill BR, Geschwind DH. Genetic advances in autism: heterogeneity and convergence on shared pathways. Curr. Opin. Genet. Dev. 2009; 19:271-8. |
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