Irisin Recombinant Protein Cat. No.: 90-316

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psi-iconSpecifications
SPECIES:Human, Mouse
SOURCE SPECIES:CHO cells
SEQUENCE:Irisin (human, aa 32-143 /mouse, aa 29-140) is DDDDK-tagged at the N-terminus. Irisin has 100% identity between mouse, rat, monkey and human.
FUSION TAG:DDDDK Tag
TESTED APPLICATIONS:
APPLICATIONS:This recombinant proteins is for research use only.
BIOLOGICAL ACTIVITY: Activates brown adipocyte markers Ucp1 and Cidec in murine subcutaneous adipocytes at 10ng/ml [Lit. 1].
psi-iconProperties
PURITY:>95% (SDS-PAGE).

Endotoxin level is less than 0.01EU/ μg purified protein (LAL test; Lonza).
PHYSICAL STATE:Lyophilized
BUFFER:Contains PBS. Reconstitute with 100 μl sterile water.
CONCENTRATION:0.1mg/ml after reconstitution.
STORAGE CONDITIONS:Stable for at least 6 months after receipt when stored at -20˚C.
psi-iconAdditional Info
ALTERNATE NAMES:Fibronectin Type III Domain-containing Protein 5 (cleaved), Fibronectin Type III Repeat-containing Protein 2 (cleaved), FNDC5 (cleaved)
ACCESSION NO.:Q8NAU1
PROTEIN GI NO.:403314395
OFFICIAL SYMBOL:FNDC5
GENE ID:252995
psi-iconBackground and References
BACKGROUND:Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.

FOR RESEARCH USE ONLY.

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