Datasheet

IRF2BP2 Antibody
CATALOG NUMBER: 5601

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human
HOMOLOGY:Predicted species reactivity based on immunogen sequence: Mouse: (100%)
TESTED APPLICATIONS:ELISA, IHC-P
APPLICATIONS:IRF2BP2 antibody can be used for detection of IRF2BP2 by immunohistochemistry at 5 μg/mL.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1201 - HeLa Cell Lysate
SPECIFICITY:At least two isoforms of IRF2BP2 are known to exist; this antibody will detect both.
IMMUNOGEN:IRF2BP2 antibody was raised against an 17 amino acid synthetic peptide near the amino terminus of human IRF2BP2.

The immunogen is located within amino acids 150 - 200 of IRF2BP2.
HOST SPECIES:Rabbit

Properties

PURIFICATION:IRF2BP2 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:IRF2BP2 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:IRF2BP2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:IRF2BP2 Antibody: Interferon regulatory factor 2-binding protein 2, IRF-2-binding protein 2
ACCESSION NO.:NP_892017
PROTEIN GI NO.:116734704
OFFICIAL SYMBOL:IRF2BP2
GENE ID:359948

Background

BACKGROUND:IRF2BP2 Antibody: IRF2BP2, like the related protein IRF2BP1, is a co-repressor that interacts specifically with the C-terminal repression domain of Interferon Regulatory Factor 2 (IRF2). IRF2BP2 is a direct target gene of p53 and is involved in cell survival during the p53 stress response, able to impede the p53-mediated transactivation of p21 and Bax. IRF2BP2 is also a co-factor of VGLL4 and is required to induce the expression of vascular endothelial growth factor A (VEGF-A) in muscle. It is normally found in the nucleus of skeletal muscle and cardiac cells, but can be found in the cytoplasm during skeletal muscle differentiation.
REFERENCES: 1) Childs KS and Goodbourn S. Identification of novel co-repressor molecules for interferon regulatory factor-2. Nuc. Acids Res. 2003; 31:3016-26.
2) Koeppel M, van Heeringen SJ, Smeenk L, et al. The novel p53 target gene IRF2BP2 participates in cell survival during the p53 stress response. Nuc. Acids Res. 2009; 37:322-35.
3) Teng ACT, Kuraitis D, Deeke SA, et al. IRF2BP2 is a skeletal and cardiac muscle-enriched ischemia-inducible activator of VEGFA expression. FASEB J. 2010; 24:4825-34.
4) Teng ACT, Al-montashiri NAM, Cheng BLM, et al. Identification of a phosphorylation-dependent nuclear localization motif in interferon regulatory factor 2 binding protein 2. PLoS One 2011; 6:e24100.

For Research Use Only