Influenza A virus Neuraminidase Recombinant Protein Cat. No.: 96-372

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psi-iconSpecifications
SPECIES:Influenza A
SOURCE SPECIES:HEK293 cells
SEQUENCE:His 36 - Lys 449
FUSION TAG:His Tag
TESTED APPLICATIONS:WB
APPLICATIONS:This recombinant protein can be used for WB. For research use only.
BIOLOGICAL ACTIVITY: Measured by its ability to cleave a fluorogenic substrate, 2'-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid. One unit is defined as the amount of enzyme required to cleave 1 nmole of 2'-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid per minute at pH 7. 5 at 37˚C.
psi-iconProperties
PURITY:>92% as determined by SDS-PAGE.
PREDICTED MOLECULAR WEIGHT:46.1 kDa
PHYSICAL STATE:Lyophilized
BUFFER:PBS, pH7.4
STORAGE CONDITIONS:Lyophilized Protein should be stored at -20˚C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚C or -70˚C. Avoid repeated freeze-thaw cycles.
psi-iconAdditional Info
ALTERNATE NAMES:NA, Neuraminidase
ACCESSION NO.:H8PF47
psi-iconBackground and References
BACKGROUND:Neuraminidase (NA) and hemagglutinin (HA) are major membrane glycoproteins found on the surface of influenza virus. Hemagglutinin binds to the sialic acid-containing receptors on the surface of host cells during initial infection and at the end of an infectious cycle. Neuraminidase, on the other hand, cleaves the HA-sialic acid bondage from the newly formed virions and the host cell receptors during budding. Neuraminidase thus is described as a receptor-destroying enzyme which facilitates virus release and efficient spread of the progeny virus from cell to cell.
REFERENCES:1) Manz B., et al., 2012, Submitted to the EMBL/GenBank/DDBJ databases.

FOR RESEARCH USE ONLY.

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