Cytokine Storm Research Reagents

Cytokine storm research reagents

What is Cytokine Storm?

Referring to the overproduction of cytokines as an inflammatory response due to infection, the named “cytokine storm” has various causes, including infections by bacteria and viruses such as SARS-CoV-2. Cytokines are proteins secreted by the immune system and promote the body’s immune response. While helpful in mediating an immune response and controlling infection, an overproduction of cytokines can be harmful to the host. Learn more from ProSci's blog! ProSci provides cytokines and chemokines for research, which include:


Interferons

Interferons are cytokines released in response to viral infection to inhibit viral replication. One interferon associated with COVID-19 is IFN-gamma. Below is a select list of ProSci’s IFN-gamma antibodies and proteins:

IFN-y Antibodies

ProductCat. No.ApplicationClonalityHost
IFN gamma Antibody [NIB42] 77-053 Flow, Neut Monoclonal Mouse
IFN gamma Antibody [NIB42] 77-054 Flow, Neut Monoclonal Mouse
IFNG Antibody 14-432 WB, IHC Polyclonal Rabbit
IFN-gamma Antibody XP-5155 E, WB, Neut Polyclonal Rabbit
IFN-gamma Antibody [1.1-5A9-2D05] XP-5739-M E, WB Monoclonal Mouse
IFNgamma Antibody [3F1E3] 32-173 E, WB Monoclonal Mouse
IFN-gamma Antibody [A35] 99-643 Flow Monoclonal Mouse
IFN-gamma Antibody [B27] 99-644 E, WB, IHC-P, IHC-Fr, ICC, Flow, IP Monoclonal Mouse
IFN-gamma Antibody [B27] 99-648 Flow Monoclonal Mouse
Interferon gamma Antibody [G-23] 33-406 Flow, IF Monoclonal Mouse

IFN-y Recombinant Proteins

ProductCat. No.SourceFusion TagSequence
IFN gamma Recombinant Protein 40-277 E. coli Gln 24 - Gln 166
IFN gamma Recombinant Protein 91-012 E. coli Tag Free Gln 24 - Gln 166
IFN-gamma R1 Recombinant Protein 96-889 HEK293 cells His Tag Asp 22 - Glu 258
IFN-y Recombinant Protein 40-557 E. coli Gln 24 - Gln 166
Interferon gamma Recombinant Protein (HEK293 Expressed) 96-409 HEK293 cells N-Fc Tag Gly 49 - Ala 118


Interleukins

Interleukins are glycoproteins that regulate the immune response. One of note in SARS-CoV-2 infections is interleukin-6 (IL-6), as blood levels of this protein correlate with COVID-19 mortality, indicating this protein as a potential biomarker or even as a potential therapeutic target for controlling the inflammatory response. IL-6 production is increased by IL-1β and TNF-α. It has been shown serum cytokine levels of IL-1β increase as well. Below is a select list of ProSci’s interleukin antibodies and proteins:

IL-6 and IL-1β Antibodies

ProductCat. No.ApplicationClonalityHost
IL-1 beta Antibody 43-610 E, WB Polyclonal Goat
IL1B Antibody 13-921 WB, IF Polyclonal Rabbit
IL1B Antibody 14-001 WB Polyclonal Rabbit
IL1B Antibody 14-002 WB, IF Polyclonal Rabbit
IL1B Antibody 16-529 WB, IHC, IF Polyclonal Rabbit
IL1B Antibody 16-928 WB, IF Polyclonal Rabbit
IL1B Antibody 63-506 WB, IHC-P, Flow Polyclonal Rabbit
IL6 Antibody 13-129 WB, IHC, IF Polyclonal Rabbit
IL6 Antibody 13-918 WB, IHC, IF Polyclonal Rabbit
IL6 Antibody 15-666 WB, IF Polyclonal Rabbit
IL6 Antibody 18-652 WB, IHC, Flow Polyclonal Rabbit
IL6 Antibody 56-451 WB, IHC-P, Flow Polyclonal Rabbit
IL6 Antibody XW-7295 E Polyclonal Chicken
IL6 Antibody 38-201 E, WB, Neut Polyclonal Goat
IL6 Antibody XP-5192 E, WB, Neut Polyclonal Rabbit
IL-6 Antibody [1.2-2B11-2G10] XP-5704-M E, WB Monoclonal Mouse
IL-6 Antibody [6D9A1,6C12B1] 48-736 E, WB, IHC Monoclonal Mouse
IL-6 Antibody [6D9A1] 32-179 E, WB Monoclonal Mouse
IL-6 Antibody [MQ2-13A5] 99-661 IHC-Fr, ICC, Flow Monoclonal Rat
IL-6 Antibody [MQ2-13A5] 99-662 IHC-Fr, ICC, Flow, Blocking, IP Monoclonal Rat
IL-6 Antibody [MQ2-39C3] 99-663 Flow Monoclonal Rat

IL-6 and IL-1β Recombinant Proteins

ProductCat. No.SourceFusion TagSequence
IL-1 beta Recombinant Protein 40-241 E. coli Ala 117 - Ser 269
IL-1 beta Recombinant Protein 92-219 E. coli Tag Free Ala 117 - Ser 269
IL-1beta Recombinant Protein 40-598 E. coli Ala 117 - Ser 269
IL-6 Recombinant Protein 40-249 E. coli Pro 29 - Met 212
IL-6 Recombinant Protein 40-523 E. coli Pro 29 - Met 212
IL-6 Recombinant Protein 91-007 E. coli Tag Free Pro 29 - Met 212


Tumor Necrosis Factor

Tumor necrosis factor or TNF is a member of the TNF superfamily and is a pro-inflammatory cytokine secreted by inflammatory cells. TNF causes fever by stimulating IL-1 secretion or direct action. Aside from IL-6, high serum levels of TNF-α can also predict COVID-19 disease severity and death. Below is a select list of ProSci’s TNF antibodies and proteins:

Antibodies

ProductCat. No.ApplicationClonalityHost
Recombinant TNF-alpha Antibody [RMTNFA-1] 34-041 IF, IHC-P Recombinant Monoclonal Rabbit
TNF alpha Antibody [4C6-H8] 33-216 Flow, IHC, IF Monoclonal Mouse
TNF alpha Antibody [TMDa1-1] 33-995 IF, IHC-P Monoclonal Mouse
TNF Antibody 57-099 WB, Flow Polyclonal Rabbit
TNF Antibody [2C8] 70-240 IHC Monoclonal Mouse
TNF Antibody [M 1 C4] 51-930 E, WB, IHC Monoclonal Mouse
TNF-a Antibody XP-5282 E, WB, Neut Polyclonal Rabbit
TNF-a Antibody XP-5283 E, WB, Neut Polyclonal Goat
TNF-a Antibody XP-5284 E, WB Polyclonal Rabbit
TNF-a Antibody XP-5285 E, WB Polyclonal Goat
TNF-a Antibody XP-5286 E, WB, Neut Polyclonal Rabbit
TNF-a Antibody [2.1_4E10-1H11] XP-5711-M E, WB, Neut Monoclonal Mouse
TNF-alpha Antibody [J2D10] 33-473 WB, Flow, IF, Inhibition, Neut Monoclonal Mouse
TNF-Alpha Antibody [MAb11] 77-180 Flow, ELISA, IHC Monoclonal Mouse
TNF-Alpha Antibody [MAb11] 77-181 Flow, ELISA, IHC Monoclonal Mouse
TNF-alpha Antibody [MP6-XT22] 99-716 Flow Monoclonal Rat
TNF-alpha Antibody [MP6-XT22] 99-719 IHC-Fr, ICC, Flow, Blocking, IP, Separation, Depletion Monoclonal Rat
TNF-alpha Antibody [MP6-XT3] 99-713 WB, Flow, IP Monoclonal Rat
TNF-alpha Antibody [MP6-XT3] 99-715 Flow Monoclonal Rat
TNF-alpha Antibody [SPM543] 34-172 Flow, IF, IHC Monoclonal Mouse
TNF-α Antibody 13-123 WB, IF Polyclonal Rabbit
TNF-α Antibody 14-045 WB, IHC, IF Polyclonal Rabbit

Recombinant Proteins

ProductCat. No.SourceFusion TagSequence
TNF alpha Recombinant Protein 91-006 E. coli Tag Free Val 77 - Leu 233
TNF alpha Recombinant Protein 91-027 E. coli Tag Free High Active Mutant
TNF alpha Recombinant Protein 92-216 E. coli C-6 His tag Val 77 - Leu 233
TNF alpha Recombinant Protein 92-217 E. coli N-6 His tag Gly 57 - Leu 233
TNF alpha Recombinant Protein (HEK293 Expressed) 96-734 HEK293 cells Tag Free Val 77 - Leu 233
TNF-alpha multimeric Recombinant Protein 90-231 HEK293 cells DDDDK Tag aa 85-223
TNF-alpha Recombinant Protein 40-115 E. coli Val 77 - Leu 233
TNF-alpha Recombinant Protein 40-609 E. coli Val 77 - Leu 233
TNF-alpha Recombinant Protein 96-958 HEK293 cells His Tag Val 77 - Leu 233
TNF-alpha, Soluble Recombinant Protein 90-221 E. coli DDDDK Tag aa 85-223
TNF-alpha, Soluble Recombinant Protein 90-222 HEK293 cells DDDDK Tag aa 85-223


Chemokines

Chemokines are small cytokines that induce chemotaxis, or movement, in nearby cells. Chemokines IL-8, CCL3 (MIP-1α), CCL2 (MCP-1), CCL5, and CXCL10 are upregulated in SARS-CoV-2 infections. Below is a select list of ProSci’s chemokine antibodies and proteins:

CCL3 (MIP-1α) Antibodies

ProductCat. No.ApplicationClonalityHost
CCL3 Antibody 23-032 WB, IHC Polyclonal Rabbit
CCL3 Antibody 63-502 WB, IHC-P Polyclonal Rabbit
CCL3 Antibody 45-379 E Polyclonal Goat
MIP Antibody 18-849 WB, IHC Polyclonal Rabbit
MIP-1a Antibody 38-220 E, WB Polyclonal Rabbit
MIP-1a Antibody XP-5232 E, WB, Neut Polyclonal Goat
MIP-1a Antibody [1.2_3E8-2H6-2B6] XP-5734-M E, WB, Neut Monoclonal Mouse

CCL3 (MIP-1α) Recombinant Proteins

ProductCat. No.SourceFusion TagSequence
CCL3 Recombinant Protein 91-048 E. coli Tag Free Ser 24 - Ala 92
MIP-1 alpha Recombinant Protein 40-337 E. coli Ala 23 - Ala 92
MIP-1 alpha Recombinant Protein 40-364 E. coli Ala 23 - Ala 92
MIP-1 alpha Recombinant Protein 40-412 E. coli Ala 23 - Ala 92
MIP-1a Recombinant Protein 40-751 E. coli Ala 23 - Ala 92

CXCL8 (IL-8) Antibodies

ProductCat. No.ApplicationClonalityHost
IL8 Antibody 63-545 WB, IHC-P, IF, Flow Polyclonal Rabbit
IL8 Antibody XW-7296 E Polyclonal Chicken
IL8 Antibody XW-7719 E, WB Polyclonal Chicken
IL8 Antibody XP-5199 E, WB Polyclonal Rabbit
IL-8 Antibody [3E4D8] 32-180 E, WB Monoclonal Mouse
IL-8 Antibody [SB-84-8] XP-5706-M E, WB Monoclonal Mouse
IL8 Antibody, Monoclonal 70-132 E, WB, IHC Monoclonal Mouse
IL-8 Receptor B Antibody 51-267 IHC Polyclonal Rabbit
IL-8 Receptor B Antibody, Monoclonal 49-841 IHC, Flow Monoclonal Mouse

CXCL8 (IL-8) Recombinant Proteins

ProductCat. No.SourceFusion TagSequence
CXCL8 Recombinant Protein 40-105 E. coli Ala 23 - Ser 99
CXCL8 Recombinant Protein 91-874 Human cells C-6 His tag Glu 21 - Ser 99
IL-8 non-lytic Recombinant Protein 90-490 CHO cells Fc Tag Ala 23 - Ser 99
IL-8 non-lytic Recombinant Protein 90-491 E. coli His Tag Ser 28 - Ser 99
IL-8 Recombinant Protein 40-331 E. coli Ser 28 - Ser 99
IL-8 Recombinant Protein 90-492 E. coli His Tag Ser 28 - Ser 99
IL-8 Recombinant Protein 90-493 CHO cells Fc Tag Ser 28 - Ser 99
IL-8 Recombinant Protein 91-026 E. coli Tag Free Ser 28 - Ser 99
IL-8 Recombinant Protein 91-028 E. coli Tag Free Ser 28 - Ser 99
IL-8 Recombinant Protein (Animal Free) 40-727 E. coli Ser 28 - Ser 99

CCL2 (MCP-1) Antibodies

ProductCat. No.ApplicationClonalityHost
CCL2 Antibody 7201 E, WB, IHC-P, IF Polyclonal Rabbit
MCP-1 Antibody [1A7B8] 32-230 E, WB Monoclonal Mouse
MCP-1 Antibody [2H5] 77-028 Flow, Func, Neut Monoclonal Hamster
MCP-1 Antibody [2H5] 77-029 Flow, Func, Neut Monoclonal Hamster
MCP-1/MCAF Antibody XP-5218 E, WB Polyclonal Rabbit
MCP-1 Antibody [2.2-4H5-01A11] XP-5732-M E, WB Monoclonal Mouse

CCL2 (MCP-1) Recombinant Proteins

ProductCat. No.SourceFusion TagSequence
MCP-1 Recombinant Protein 40-362 E. coli Gln 24 - Thr 99
MCP-1 Recombinant Protein 40-564 E. coli Gln 24 - Thr 99
CCL2 Recombinant Protein 90-376 CHO cells Fc Tag Gln 24 - Thr 99
CCL2 Recombinant Protein 90-377 CHO cells Fc Tag Gln 24 - Thr 99
CCL2 Recombinant Protein 90-378 CHO cells Fc Tag Gln 24 - Asn 148
CCL2 Recombinant Protein 90-379 CHO cells Fc Tag Gln 24 - Asn 148

CCL5 Antibodies

ProductCat. No.ApplicationClonalityHost
CCL5 Antibody 28-631 E, WB Polyclonal Rabbit
CCL5 Antibody, Monoclonal 49-951 E, IHC, Neut Monoclonal Mouse
CCL5 Antibody [50013-5] 70-133 E, WB, IHC Monoclonal Mouse

CCL5 Recombinant Proteins

ProductCat. No.SourceFusion TagSequence
CCL5 Recombinant Protein 91-049 E. coli Tag Free Ser 24 - Ser 91
CCL5 Recombinant Protein 92-430 Human cells C-Fc-6 His Tag Ser 24 - Ser 91
CCL5 Recombinant Protein 90-382 E. coli His Tag Ser 24 - Ser 91
CCL5 Recombinant Protein 90-383 E. coli His Tag Ser 24 - Ser 91

CXCL10 (IP-10) Antibodies

ProductCat. No.ApplicationClonalityHost
IP-10 Antibody 38-252 E, WB, Neut Polyclonal Rabbit
IP-10 Antibody [3.3-1G1-2G7-2F6] 38-267 E, WB Monoclonal Mouse
IP-10 Antibody XP-5203 E, WB, Neut Polyclonal Rabbit
IP-10 Antibody XP-5204 E, WB, Neut Polyclonal Rabbit

CXCL10 (IP-10) Recombinant Proteins

ProductCat. No.SourceFusion TagSequence
IP-10 Recombinant Protein 40-344 E. coli Iso 22 - Pro 98
IP-10 Recombinant Protein 40-367 E. coli Iso 22 - Pro 98
IP-10 Recombinant Protein 40-416 E. coli Iso 22 - Pro 98
CXCL10 Recombinant Protein 91-043 E. coli Tag Free Iso 22 - Pro 98
CXCL10 Recombinant Protein 91-905 Human cells C-Fc-6 His Tag Iso 22 - Pro 98


Colony Stimulating Factors

Colony Stimulating Factors (CSFs) are glycoproteins associated with inflammation as they control granulocyte and macrophage production and even some functions of these cells, such as cytokine production. Below is a select list of ProSci’s CSF antibodies and proteins:

M-CSF (CSF1) Antibodies

ProductCat. No.ApplicationClonalityHost
CSF1 Antibody 13-836 WB, IHC, IF, Flow Polyclonal Rabbit
CSF1 Antibody 16-516 WB, IHC Polyclonal Rabbit
CSF1 Antibody 29-983 E, WB Polyclonal Rabbit
M-CSF Antibody 62-446 WB, IHC-P, IF, Flow Polyclonal Rabbit
M-CSF Antibody XP-5227 E, WB, Neut Polyclonal Rabbit
M-CSF Antibody XP-5228 E, WB, Neut Polyclonal Goat
MCSF Antibody [2D10] 51-394 E, WB, IHC Monoclonal Mouse

M-CSF (CSF1) Recombinant Proteins

ProductCat. No.SourceFusion TagSequence
M-CSF Recombinant Protein 40-288 E. coli See datasheet
M-CSF Recombinant Protein 40-447 E. coli Gln 33 - Pro 186
M-CSF Recombinant Protein 40-479 E. coli Gln 33 - Pro 186
M-CSF Recombinant Protein 40-606 E. coli See datasheet
M-CSF Recombinant Protein 40-620 E. coli Gln 33 - Pro 186
M-CSF Recombinant Protein 91-375 Human cells C-6 His Tag Glu 33 - Arg 255
M-CSF Recombinant Protein 91-425 E. coli Tag Free Gln 33 - Arg 254
M-CSF Recombinant Protein 91-598 Human cells C-6 His Tag Lys 33 - Glu 262
M-CSF Recombinant Protein 96-923 Human cells His Tag Lys 77 - Leu 451
M-CSF Recombinant Protein (Animal Free) 40-769 E. coli Gln 33 - Pro 186

G-CSF (CSF3) Antibodies

ProductCat. No.ApplicationClonalityHost
CSF3 Antibody 16-164 WB, IF Polyclonal Rabbit
CSF3 Antibody 22-041 WB, IHC Polyclonal Rabbit
G-CSF Antibody [CSF3/900] 33-340 Flow, IF, IHC-P Monoclonal Mouse
GCSF Antibody [SPM468] 33-341 Flow, IF, IHC-P Monoclonal Mouse
G-CSF Antibody [PRPN2-1] 33-906 IF, IHC-P Monoclonal Mouse
G-CSF receptor / CSF3R Antibody 43-704 E, WB Polyclonal Goat
CSF3 Antibody 60-580 WB Polyclonal Rabbit
G-CSF Antibody [BVD13-3A5] 99-674 Flow Monoclonal Rat
G-CSF Antibody [BVD13-3A5] 99-675 IHC-Fr, ICC, Flow, IP Monoclonal Rat
G-CSF Antibody [BVD11-37G10] 99-676 IHC-Fr, ICC, Flow Monoclonal Rat
G-CSF Antibody XP-5141 E, WB Polyclonal Rabbit
G-CSF Antibody XP-5142 E, WB, Neut Polyclonal Rabbit

G-CSF (CSF3) Recombinant Proteins

ProductCat. No.SourceFusion TagSequence
G-CSF Recombinant Protein 40-439 E. coli Val 31 - Ala 208
G-CSF Recombinant Protein 40-555 E. coli Thr 27 - Gly 176
G-CSF Recombinant Protein 40-706 E. coli Iso 22 - Iso 214
G-CSF Recombinant Protein (Animal Free) 40-746 E. coli Val 31 - Ala 208
CSF3 Recombinant Protein 90-450 CHO cells Fc Tag Val 31 - Ala 208
CSF3 Recombinant Protein 90-451 CHO cells Fc Tag Val 31 - Ala 208
CSF3 Recombinant Protein 91-001 E. coli Tag Free Thr 31 - Pro 204
CSF3 Recombinant Protein 96-785 HEK293 Thr 31 - Pro 204


Growth Factors

Growth factors regulate cell division and cell survival, playing an important role in growth. Inhibition of growth factor signaling prevents SARS-CoV-2 viral replication. Below is a select list of ProSci’s growth factor antibodies and proteins:

EGF Antibodies

ProductCat. No.ApplicationClonalityHost
EGF Antibody 38-210 E, WB, Neut Polyclonal Rabbit
EGF Antibody [9D7F11] 51-387 E, WB, IHC Monoclonal Mouse
EGF Antibody 56-711 WB, IHC-P Polyclonal Rabbit
EGF Antibody 60-331 WB Polyclonal Rabbit
EGF Antibody XP-5119 E, WB, Neut Polyclonal Rabbit
EGF Antibody XP-5120 E, WB Polyclonal Goat

EGF Recombinant Proteins

ProductCat. No.SourceFusion TagSequence
EGF Recombinant Protein 40-586 E. coli Asn 971 - Arg 1023
EGF Recombinant Protein 91-020 E. coli Tag Free Asn 971 - Arg 1023
EGF Recombinant Protein 90-455 CHO cells Fc Tag Asn 971 - Arg 1023
EGF Recombinant Protein 96-257 E. coli His Tag Asn 971 - Arg 1023
EGF Recombinant Protein 40-450 E. coli Asn 977 - Arg 1029
EGF Recombinant Protein 40-477 E. coli Asn 974 - Arg 1026
EGF Recombinant Protein 92-245 E. coli C-6 His Tag Asn 977 - Arg 1029

VEGF Antibodies

ProductCat. No.ApplicationClonalityHost
VEGFA Antibody 13-125 WB, IF, IP Polyclonal Rabbit
VEGF Antibody 14-355 WB, IF Polyclonal Rabbit
VEGFA Antibody 16-722 WB, IF Polyclonal Rabbit
VEGFA Antibody 16-830 WB Polyclonal Rabbit
VEGF Antibody [5E5E3] 18-148 WB, IHC Monoclonal Mouse
VEGF Antibody [VEGF/1063] 33-479 WB, IF, IHC-P Monoclonal Mouse
VEGF Antibody [VGFA-1] 34-006 IF, IHC-P Monoclonal Mouse
VEGF Antibody 38-206 E, WB, Neut Polyclonal Rabbit
VEGFA Antibody 43-168 E, WB, IHC Polyclonal Goat
VEGFA Antibody 56-265 WB Polyclonal Rabbit
VEGF1 Antibody 62-226 WB Polyclonal Rabbit
VEGF Antibody XP-5291 E, WB Polyclonal Rabbit
VEGF Antibody XP-5292 E, WB Polyclonal Goat
VEGF Antibody XP-5293 E, WB, Neut Polyclonal Rabbit
VEGF Antibody [4B2-8] XP-5740-M E, WB, Neut Monoclonal Mouse

VEGF Recombinant Proteins

ProductCat. No.SourceFusion TagSequence
VEGF-A Recombinant Protein 91-069 Human cells Tag Free Ala 27 - Arg 191
VEGF-A Recombinant Protein 91-584 Human cells C-6 His Tag Ala 27 - Arg 147
VEGF-A Recombinant Protein 91-589 E. coli Tag Free Ala 27 - Arg 147
VEGF-A Recombinant Protein 40-491 E. coli See datasheet
VEGF Recombinant Protein (Animal-Free) 40-773 E. coli See datasheet
VEGF-A Recombinant Protein 91-944 P. pastoris Tag Free Ala 27 - Arg 190
VEGF-A Recombinant Protein 92-494 P. pastoris Tag Free Ala 27 - Arg 190

Do not see the target you are interested in? Feel free to use our search or contact us and we would be happy to help further your research. ProSci also offers its antibody development expertise through custom antibody services – if you can’t find it, we can make it for you! Visit prosci-services.com for more information.



References