ACE2 Receptor Research Reagents

SARS-CoV-2 (COVID-19) Receptor ACE2 antibodies and proteins

ACE2 & Other Related Target Reagents

To support the efforts of researchers worldwide in understanding and combating the COVID-19 virus (SARS-COV-2) and other coronaviruses, ProSci Incorporated provides validated coronavirus receptor ACE2 antibodies, as well as related targets. Check out our ACE2 Antibody (Cat. No. 3217) that was cited in Cell.


What is the ACE2 receptor?

Angiotensin-converting enzyme 2 (ACE2) is an essential regulator of heart function expressed in the heart, lung, kidney, and gastrointestinal tract. In addition, ACE2 is a functional receptor that acts as an entry point into human lung cells for coronaviruses such as SARS and novel coronavirus SARS-CoV-2. Research in SARS-COV-2 and ACE2 interaction is a topic of interest since it plays a key role in both cross-species and human-to-human transmissions of SARS-CoV-2.[i].

SARS-CoV Antibodies

ACE2 receptors interact with the spike protein (S) of SARS-COV-2 as confirmed by structural analysis of SARS-COV-2. The SARS-COV-2  spike protein receptor-binding domain structure is similar to the SARS spike protein[ii] suggesting a similar function. In a study on SARS-CoV, the virus infection occurred in well-differentiated ciliated epithelial cells expressing ACE2 thus the virus enters hosts through the mucosa of the respiratory and gastrointestinal tract.[iii]     


ACE2 Receptor Reagents

ProSci offers antibodies and recombinant proteins for the ACE2 receptor:

Antibodies

ProductCat. No.ApplicationClonality
ACE2 Antibody 3215 ELISA, IF, IHC-P, WB Polyclonal
ACE2 Antibody 3217 ELISA, IF, IHC-P, WB Polyclonal 
ACE2 Antibody 3227 ELISA, IF, IHC-P, WB Polyclonal 
ACE2 Antibody 3229 ELISA, IF, IHC-P, WB Polyclonal 
ACE2 Antibody 24-033 WB, IHC Polyclonal
ACE2 Antibody [3F1] 10-604 WB, IF, IHC Monoclonal
ACE2 Antibody[AC18F] 36-031 ELISA, Flow, WB Monoclonal 
ACE2 Antibody[AC18F](biotin) 36-032 ELISA, Flow, WB Monoclonal 
ACE2 Antibody[AC384] 36-038 ELISA, WB Monoclonal 
ACE2 Antibody[AC384](biotin) 36-039 ELISA, WB Monoclonal 

Recombinant Proteins

ProductCat. No.SourceFusion TagSequence
Human ACE2 Recombinant Protein 10-421 Mammalian Cells C-His Tag Ser19 - Asp615
Human ACE2 Recombinant Protein 10-430 E. Coli N-His Tag Leu392 - Ser740
Human ACE2 Recombinant Protein 10-432 Mammalian Cells Tag Free Met1 - Ser740
Human ACE2 Recombinant Protein 10-114 Human Cells C-His-Avi Tag Gln18 - Ser740
Human ACE2 Recombinant Protein 10-120 Human Cells C-Fc Tag Gln18 - Ser740
Biotinylated Human ACE2 Recombinant Protein 10-202 HEK293 Cells His-Avi Tag Gln18 - Ser740
ACE2 Recombinant Protein 92-724 Human Cells C-10 His Tag Gln18 - Thr740
Rhesus Macaque ACE2 Recombinant Protein 92-725 Human Cells C-10 His Tag Gln18 - Val739
Rhesus Macaque ACE2 Recombinant Protein 92-726 Human Cells C-Fc Tag Gln18 - Val739


SARS-CoV-2 (COVID-19) Protease TMPRSS2 Antibody

ProductCat. No.ApplicationClonality
TMPRRS2 Antibody 24-034 IHC, WB Monoclonal 
TMPRRS2 Antibody 46-908 ELISA, WB Polyclonal 
TMPRRS2 Antibody 18-426 IHC, WB Polyclonal 
TMPRRS2 Antibody 62-863 Flow, WB Polyclonal 


SARS-CoV-2 (COVID-19) Furin Antibody

ProductCat. No.ApplicationClonality
Furin Antibody 22-945 IHC, WB Polyclonal 
Furin Antibody 14-925 WB Polyclonal 
Furin Antibody 43-351 ELISA, WB Polyclonal 


SARS-CoV-2 (COVID-19) Furin Recombinant Protein

ProductCat. No.SourceFusion TagSequence
Furin Recombinant Protein 40-542 HEK cells His Asp108-Glu715




References

[i] Wan Y, Shang J, Graham R, Baric RS, Li F. Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS https://doi.org/10.1128/JVI.00127-20

[ii] Lu R, Zhao X, Li J, et al. Genomic characterization and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding pdf icon[1.35 MB, 10 pages]. The Lancet. Published online January 29, 2020. https://doi.org/10.1016/ S0140-6736(20)30251-8

[iii] Jia HP, Look DC, Shi L, et al. ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia. J Virol. 2005;https://doi.org/10.1128/JVI.79.23.14614-14621.2005