SARS Coronavirus 2 (SARS-CoV-2) Research Reagents

SARS-CoV-2 (COVID-19, 2019-nCoV) research reagents - antibodies and recombinant proteins for all structural proteins for SARS-CoV-2 

SARS-CoV-2 (COVID-19) Research Reagents

The SARS-CoV-2 structural proteins (1) spike (S), membrane (M), envelope (E), and nucleocapsid (N), serve as cytological markers for viral sites of infection including cell-to-cell transmissibility. ProSci Inc. offers Antibodies validated by patient samples and Antibodies specific for Variants (Cat. No. 9359) as well as Antibodies Variant-Independent for cytological use – IHC, IF. For example, Spike Antibody, Cat. No. 3525, targets the conserved intracellular domain of the spike protein. This serves as a powerful reagent for use in IHC, ICC, and IF (2). Research reagents additionally include Antibodies against host factors ACE2 receptor, TMPRSS2, and furin (3).

SARS-CoV-2 Proteome

Diagram of SARS-CoV-2 proteome

Click on your Target of Interest to go to a specific product

ProSci Inc. offers antibodies and recombinant proteins for all SARS-CoV-2 targets:


More Areas of SARS-CoV-2 Research

SARS-CoV-2 Variant Antibodies and Recombinant Proteins

The use of the ProSci Spike Antibody (Cat. No. 3525) has been cited in numerous publications in 2020 and 2021. Of great interest now, while ProSci offers antibodies and recombinant proteins representing the full SARS-CoV-2 proteome, and host factors, the company also has a catalog of spike S1 antibodies to variant SARS-CoV-2 B.1.1.7 (Alpha) to the P681H point mutation (Cat. No. 9359) – this residue is adjacent to the Furin cleavage site, required for viral cell entry.

COVID-19 Patient Sample Validated Antibodies

ProSci enhances research efforts globally to understand this virus and its health effects. We have validated antibodies to all four structural proteins and several non-structural SARS-CoV-2 proteins by IHC with COVID-19 positive patient tissue samples, showing that these antibodies can detect the
virus itself.

Matched Pair Antibodies

ProSci offers SARS-CoV-2 antibody pairs validated by sandwich ELISA. These matched pair antibodies include antibodies against Spike S1, Spike RBD, and Nucleocapsid proteins. Some of the antibodies have been validated with COVID-19 patient samples.


SARS-CoV-2-related Citations

ProSci is continuing to dedicate time and effort to the research of the SARS-CoV-2 virus responsible for the COVID-19 pandemic. Our antibodies have been cited in the journals such as Cell, Nature Microbiology, The Journal of Vaccum Science and Technology B, and many more. Check out how ProSci antibodies and recombinant proteins were used in these studies, and how they can benefit you for yours!



References

  • (1) Fehr AR, Perlman S. Coronaviruses: an overview of their replication and pathogenesis. Methods Mol Biol. 2015;1282:1–23. https://doi.org/10.1007/978-1-4939-2438-7_1

  • (2) Singh, et al. Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons, and marmosets. Nat Microbiol. 2021 Jan;6(1):73-86. DOI: 10.1038/s41564-020-00841-4. Epub 2020 Dec 18PMID: 33340034

  • (3) Hoffmann, M., Kleine-Weber, H., Schroeder, S., et al.   SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. S0092–8674(20)30229–4 Advance online publication. https://doi.org/10.1016/j.cell.2020.02.052