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TIM-3 Immune Checkpoint

The immune checkpoint protein TIM-3 is a member of the immunoglobulin superfamily and TIM family of proteins that was initially identified as a specific marker of fully differentiated IFN-γ producing CD4 T helper 1 (Th1) and CD8 cytotoxic cells. It is a Th1-specific cell surface protein that regulates macrophage activation and negatively regulates Th1-mediated auto- and alloimmune responses, and is also highly expressed on regulatory T cells, monocytes, macrophages, and dendritic cells (1).TIM-3 and PD-1 are co-expressed on most CD4 and CD8 T cells infiltrating solid tumors or in hematologic malignancy in mice; blocking TIM3 in conjugation with a PD-1 blockade increases the functionality of exhausted T cells and synergizes with to inhibit tumor growth (2,3).

TIM-3 Matched Pair Antibody Sets

A sandwich ELISA was performed using anti-TIGIT mouse monoclonal antibodies to capture the TIGIT extracellular domain antigen and anti-TIGIT single domain antibodies for detection.

TargetCat.no.CaptureDetectionHostDatasheet
TIM-3 Antibody PairRFP-1001RF16104RF16103-BiotinMouse - Mouse

Mouse Monoclonal TIM-3 Antibodies

ProSci's monoclonal immune checkpoint antibodies made to improve in vitro studies. Unlike antibodies developed using proteins made in yeast or bacteria, these TIM-3 antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein. They are guaranteed to work for their tested applications.

Mouse Monoclonal TIM-3 Antibody Set

Sets consist of 20µg aliquots of several mouse monoclonal antibodies with different binding features allowing for selection of the best clone for your application.

Product SetContents
Risk-Free TIM-3 Set (RF16100)RF16103, RF16104, RF16105, RF16106, RF16107, RF16108, RF16109

Mouse Monoclonal TIM-3 Antibodies

ProSci’s Risk-Free TIM-3 antibodies are rigorously tested and guaranteed to work for their designated applications. TIM-3 antibodies were raised against the extracellular domain of human TIM-3.

Cat. No.ELISAWBICCIFIHCFlow
RF16103
RF16104
RF16105
RF16106
RF16107
RF16108
RF16109
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KEY: =Negative =Fair =Average =Good =Excellent

Related Products

Cat. No.Product TypeSource
RF16100-01Recombinant ProteinHEK293

Polyclonal TIM-3 Antibodies

Cat. No.NameHostClonalityApplications
8659TIM-3 AntibodyRabbitPolyclonalELISA, IF, IHC-P, WB

For additional information on TIM-13, visit

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