TIM-3 Immune Checkpoint
The immune checkpoint protein TIM-3 is a member of the immunoglobulin superfamily and TIM family of proteins that was initially identified as a specific marker of fully differentiated IFN-γ producing CD4 T helper 1 (Th1) and CD8 cytotoxic cells. It is a Th1-specific cell surface protein that regulates macrophage activation and negatively regulates Th1-mediated auto- and alloimmune responses, and is also highly expressed on regulatory T cells, monocytes, macrophages, and dendritic cells (1).TIM-3 and PD-1 are co-expressed on most CD4 and CD8 T cells infiltrating solid tumors or in hematologic malignancy in mice; blocking TIM3 in conjugation with a PD-1 blockade increases the functionality of exhausted T cells and synergizes with to inhibit tumor growth (2,3).
TIM-3 Matched Pair Antibody Sets
A sandwich ELISA was performed using anti-TIGIT mouse monoclonal antibodies to capture the TIGIT extracellular domain antigen and anti-TIGIT single domain antibodies for detection.
| Target | Cat.no. | Capture | Detection | Host | Datasheet |
|---|---|---|---|---|---|
| TIM-3 Antibody Pair | RFP-1001 | RF16104 | RF16103-Biotin | Mouse - Mouse |  |
Mouse Monoclonal TIM-3 Antibodies
ProSci's monoclonal immune checkpoint antibodies made to improve in vitro studies. Unlike antibodies developed using proteins made in yeast or bacteria, these TIM-3 antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein. They are guaranteed to work for their tested applications.
Mouse Monoclonal TIM-3 Antibody Set
Sets consist of 20µg aliquots of several mouse monoclonal antibodies with different binding features allowing for selection of the best clone for your application.
Mouse Monoclonal TIM-3 Antibodies
ProSci’s Risk-Free TIM-3 antibodies are rigorously tested and guaranteed to work for their designated applications. TIM-3 antibodies were raised against the extracellular domain of human TIM-3.
Related Products
| Cat. No. | Product Type | Source |
|---|---|---|
| RF16100-01 | Recombinant Protein | HEK293 |
Polyclonal TIM-3 Antibodies
| Cat. No. | Name | Host | Clonality | Applications |
|---|---|---|---|---|
| 8659 | TIM-3 Antibody | Rabbit | Polyclonal | ELISA, IF, IHC-P, WB |
For additional information on TIM-13, visit