LAG-3 Immune Checkpoint

 

The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2).  It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4).   LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions.  Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy (5).


risk free immune monoclonal antibody icon

Risk-Free™ Mouse Monoclonal LAG-3 Products

ProSci's Risk-Free™ antibodies are monoclonal antibodies made to improve in vivo studies. Unlike antibodies developed using proteins made in yeast or bacteria, Risk-Free™ LAG-3 antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein. Risk-Free™ means they are guaranteed to work for their approved applications.
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Risk-Free™ Mouse Monoclonal LAG-3 Set

ProSci's Risk-Free™ Sets consists of several mAbs with different binding features allowing selection of the best clone.

Product SetSizeContentsDescription
Risk-Free LAG-3 Set (RF16080) 20μg / Clone RF16082, RF16083, RF16084, RF16086, RF16087, RF16088, RF16089 Mouse monoclonal LAG-3 antibodies were raised against the extracellular domain of human LAG-3.

Risk-Free™ Mouse Monoclonal LAG-3 Antibodies

ProSci Risk-Free™ LAG-3 antibodies are rigorously tested and guaranteed to work for their designated applications.

= Negative = Fair   = Average    = Good     = Excellentbest application= Best Application
Cat. No.ELISAWBICCIFIHCFlowConjugation
RF16082 Host Species: Mouse
Reactivity: Human
   RF16082 LAG-3 ELISA
ELISA Titration Curve Analysis
  RF16082 LAG-3 Western Blot
WB in HEK293 Cells
   RF16082 LAG-3 Immunocytochemistry
ICC in HEK293 Cells
   RF16082 LAG-3 Immunofluorescence
IF in HEK293 Cells
   RF16082 LAG-3 Immunohistochemistry
IHC in Human Lymph Node
   RF16082 LAG-3 Flow Cytometry
Flow in HEK293 Cells
Available
RF16083 Host Species: Mouse
Reactivity: Human
 RF16083 LAG-3 ELISA
ELISA Titration Curve Analysis
     RF16083 LAG-3 Immunocytochemistry
ICC in HEK293 Cells
         RF16083 LAG-3 Flow Cytometry
Flow in HEK293 Cells
Available
RF16084 Host Species: Mouse
Reactivity: Human
   RF16084 LAG-3 ELISA
ELISA Titration Curve Analysis
     RF16084 LAG-3 Immunocytochemistry
ICC in HEK293 Cells
  RF16084 LAG-3 Immunofluorescence
IF in HEK293 Cells
  RF16084 LAG-3 Immunohistochemistry
IHC in Human Lymph Node
   RF16084 LAG-3 Flow Cytometry
Flow in HEK293 Cells
Available
RF16086 Host Species: Mouse
Reactivity: Human
        RF16086 LAG-3 Immunocytochemistry
ICC in HEK293 Cells
  RF16086 LAG-3 Immunofluorescence
IF in HEK293 Cells
  RF16086 LAG-3 Immunohistochemistry
IHC in Human Lymph Node
   Available
RF16087 Host Species: Mouse
Reactivity: Human
        RF16087 LAG-3 Immunocytochemistry
ICC in HEK293 Cells
  RF16087 LAG-3 Immunofluorescence
IF in HEK293 Cells
  RF16087 LAG-3 Immunohistochemistry
IHC in Human Lymph Node
   Available
RF16088 Host Species: Mouse
Reactivity: Human
   RF16088 LAG-3 ELISA
ELISA Titration Curve Analysis
   RF16088 LAG-3 Western Blot
WB in HEK293 Cells
  RF16088 LAG-3 Immunocytochemistry
ICC in HEK293 Cells
  RF16088 LAG-3 Immunofluorescence
IF in HEK293 Cells
  RF16088 LAG-3 Immunohistochemistry
IHC in Human Lymph Node
  RF16088 LAG-3 Flow Cytometry
Flow in HEK293 Cells
Available
RF16089 Host Species: Mouse
Reactivity: Human
   RF16089 LAG-3 ELISA
ELISA Titration Curve Analysis
   RF16089 LAG-3 Western Blot
WB in HEK293 Cells
  RF16089 LAG-3 Immunocytochemistry
ICC in HEK293 Cells
  RF16089 LAG-3 Immunofluorescence
IF in HEK293 Cells
  RF16089 LAG-3 Immunohistochemistry
IHC in Human Lymph Node
  RF16089 LAG-3 Flow Cytometry
Flow in HEK293 Cells
Available

immune checkpoints single domain icon

Risk-Free™ Single Domain Monoclonal LAG-3 Products

Llama single domain antibodies (sdAbs) offer unique characteristics amenable to many applications. These sdAbs demonstrate low nanomolar binding affinity and can be used for the various applications. Note: LAG-3 antibody should be stored in working aliquots at -20 °C, stable for up to one year. As with all antibodies, care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Risk-Free™ Single Domain Monoclonal LAG-3 Set

ProSci's Risk-Free™ Sets consists of several mAbs with different binding features allowing selection of the best clone.

Product SetSizeContentsDescription
Single Domain LAG-3 Set (SD8700) 20μg / Clone SD8837, SD8839, SD8841, SD8842, SD8843 Llama single domain monoclonal LAG-3 antibodies were raised against a recombinant protein corresponding to amino acids 23-434 of human LAG-3.

Risk-Free™ Single Domain Monoclonal LAG-3 Antibodies

= Negative = Fair   = Average    = Good     = ExcellentSingle Domain Best Application= Best Application
Cat. No.ELISAWBICCIFIHCFlowConjugation
SD8837 Host Species: Llama
Reactivity: Human
   SD8837 LAG-3 ELISA
ELISA Titration Curve Analysis
        SD8837 LAG-3 Immunofluorescence
IF in HEK293 Cells
  SD8837 LAG-3 Immunohistochemistry
IHC in Human Lymph Node
  SD8837 LAG-3 Flow Cytometry
Flow in HEK293 Cells
Available
SD8839Host Species: Llama
Reactivity: Human
   SD8839 LAG-3 ELISA
ELISA Titration Curve Analysis
        SD8839 LAG-3 Immunofluorescence
IF in HEK293 Cells
  SD8839 LAG-3 Immunohistochemistry
IHC in Human Lymph Node
  SD8839 LAG-3 Flow Cytometry
Flow in HEK293 Cells
Available
SD8841Host Species: Llama
Reactivity: Human
     SD8841 LAG-3 ELISA
ELISA Titration Curve Analysis
         SD8841 LAG-3 Immunofluorescence
IF in HEK293 Cells
   SD8841 LAG-3 Immunohistochemistry
IHC in Human Lymph Node
  SD8841 LAG-3 Flow Cytometry
Flow in HEK293 Cells
Available
SD8842Host Species: Llama
Reactivity: Human
     SD8842 LAG-3 ELISA
ELISA Titration Curve Analysis
       SD8842 LAG-3 Immunofluorescence
IF in HEK293 Cells
  SD8842 LAG-3 Immunohistochemistry
IHC in Human Lymph Node
SD8842 LAG-3 Flow Cytometry
Flow in HEK293 Cells
Available
SD8843Host Species: Llama
Reactivity: Human
     SD8843 LAG-3 ELISA
ELISA Titration Curve Analysis
       SD8443 LAG-3 Immunofluorescence
IF in HEK293 Cells
 SD8843 LAG-3 Immunohistochemistry
IHC in Human Lymph Node
  SD8843 LAG-3 Flow Cytometry
Flow in HEK293 Cells
Available

Related Products

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Antigen


Cat. No.Product TypeSpeciesTissue/CellDatasheet
RF16080-01 Recombinant Protein Human HEK293
 
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Lysates


Cat. No.Product TypeSpeciesNameDatasheet
RF10001-03 Positive Control (Tissue Lysate) Human Spleen
RF10001-02 Negative Control (Cell Lysate) Human HEK293
 
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Slides


Cat. No.Product TypeSpeciesNameDatasheet
RF10002-03 Positive Control (Tissue Lysate) Human Spleen
RF10002-02 Negative Control (Cell Lysate) Human HEK293
 
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Conjugates


Cat. No.HRPBiotinCustom
RF16082 Not Available Available Contact Us
RF16083 Not Available Available Contact Us
RF16084 Not Available Available Contact Us
RF16088 Not Available Available Contact Us
RF16089 Not Available Available Contact Us
 

Additional Antibody LAG-3 Products

Monoclonal antibodies are highly specific and recognize only one epitope on an antigen which generates consistent performance in quantitative detection applications regardless of production batch. Polyclonal antibodies have high affinity and recognize different epitopes on a specific antigen. Note: These antibodies can be stored at -20˚C and are stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.


Monoclonal LAG-3 Products

Cat. No.NameApplicationsDatasheet
36-105Host Species: Mouse
Reactivity:Human, Monkey
LAG-3 Antibody [11E3] ELISA, Func, ICC, IHC, IP, WB
36-106Host Species: Mouse
Reactivity: Human, Monkey
LAG-3 Antibody [11E3] (PE) ELISA, Func, ICC, IHC, IP, WB
36-107Host Species: Mouse
Reactivity: Human
LAG-3 Antibody [17B4] Func, ICC, IHC, IP, WB
36-108Host Species: Mouse
Reactivity: Human
LAG-3 Antibody [17B4] (PE) Func, ICC, IHC, IP, WB
36-109Host Species: Mouse
Reactivity: Human
LAG-3 Antibody [17B4] (biotin) ELISA
36-110Host Species: Human
Reactivity: Human
LAG-3 Antibody [17B4] (FITC) Flow
36-111Host Species: Mouse
Reactivity: Human
LAG-3 Antibody [17B4] (ATTO 590) ICC
36-112Host Species: Mouse
Reactivity: Human
LAG-3 Antibody [17B4] (ATTO 488) Flow, ICC
36-113Host Species: Mouse
Reactivity: Human
LAG-3 Antibody [17B4] (ATTO 647N) Flow, ICC

Polyclonal LAG-3 Products

Cat. No.NameApplicationsDatasheet
8655Host Species: Rabbit
Reactivity:Human, Mouse
LAG-3 Antibody ELISA, IF, IHC-P, WB
62-572Host Species: Rabbit
Reactivity: Human, Mouse
LAG3 Antibody IHC-P

Additional LAG-3 Information

 

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