LAG-3 Immune Checkpoint

 

The lymphocyte activation gene-3 (LAG3) is a member of the immunoglobulin superfamily and binds MHC class II with high affinity (1), negatively regulating T-cell function and homeostasis (2).  It is expressed in B, T, and NK cells, monocytes, and dendritic cells (3), and acts to regulate T cell expansion (4).   LAG3 is also an important immune checkpoint protein, with anti-LAG3 antibodies activating T effector cells and affecting regulatory T cell functions.  Furthermore LAG3 appears to act in a synergistic fashion with PD-1/PD-L1, suggesting that a dual antibody approach may prove useful in cancer immunotherapy (5).


Risk-Free™ Mouse Monoclonal LAG-3 Products

ProSci's Risk-Free™ antibodies are monoclonal antibodies made to improve in vivo studies. Unlike antibodies developed using proteins made in yeast or bacteria, Risk-Free™ LAG-3 antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein. Risk-Free™ means they are guaranteed to work for their approved applications.
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Risk-Free™ Mouse Monoclonal LAG-3 Set

ProSci's Risk-Free™ Sets consists of several mAbs with different binding features allowing selection of the best clone.

Product SetSizeContentsDescription
Risk-Free LAG-3 Set (RF16080) 20μg / Clone RF16082, RF16083, RF16084, RF16086, RF16087, RF16088, RF16089 Mouse monoclonal LAG-3 antibodies were raised against the extracellular domain of human LAG-3.

Risk-Free™ Mouse Monoclonal LAG-3 Antibodies

ProSci Risk-Free™ LAG-3 antibodies are rigorously tested and guaranteed to work for their designated applications.

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= Negative = Fair   = Average    = Good     = Excellent= Best Application
Cat. No.ELISAWBICCIFIHCFlowConjugation
RF16082 Host Species: Mouse
Reactivity: Human
   
ELISA Titration Curve Analysis
  
WB in HEK293 Cells
   
ICC in HEK293 Cells
   
IF in HEK293 Cells
   
IHC in Human Lymph Node
   
Flow in HEK293 Cells
Available
RF16083 Host Species: Mouse
Reactivity: Human
 
ELISA Titration Curve Analysis
     
ICC in HEK293 Cells
         
Flow in HEK293 Cells
Available
RF16084 Host Species: Mouse
Reactivity: Human
   
ELISA Titration Curve Analysis
     
ICC in HEK293 Cells
  
IF in HEK293 Cells
  
IHC in Human Lymph Node
   
Flow in HEK293 Cells
Available
RF16086 Host Species: Mouse
Reactivity: Human
        
ICC in HEK293 Cells
  
IF in HEK293 Cells
  
IHC in Human Lymph Node
   Available
RF16087 Host Species: Mouse
Reactivity: Human
        
ICC in HEK293 Cells
  
IF in HEK293 Cells
  
IHC in Human Lymph Node
   Available
RF16088 Host Species: Mouse
Reactivity: Human
   
ELISA Titration Curve Analysis
   
WB in HEK293 Cells
  
ICC in HEK293 Cells
  
IF in HEK293 Cells
  
IHC in Human Lymph Node
  
Flow in HEK293 Cells
Available
RF16089 Host Species: Mouse
Reactivity: Human
   
ELISA Titration Curve Analysis
   
WB in HEK293 Cells
  
ICC in HEK293 Cells
  
IF in HEK293 Cells
  
IHC in Human Lymph Node
  
Flow in HEK293 Cells
Available

Risk-Free™ Single Domain Monoclonal LAG-3 Products

Llama single domain antibodies (sdAbs) offer unique characteristics amenable to many applications. These sdAbs demonstrate low nanomolar binding affinity and can be used for the various applications. Note: LAG-3 antibody should be stored in working aliquots at -20 °C, stable for up to one year. As with all antibodies, care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Coming Soon

  • Immunization
  • PBMC Isolation
  • Library Construction
  • Validation
  • Release

If you want to be notified when this target will be released, let us know.

Related Products

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Antigen


Cat. No.Product TypeSpeciesTissue/CellDatasheet
RF16080-01 Recombinant Protein Human HEK293
 
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Lysates


Cat. No.Product TypeSpeciesNameDatasheet
RF10001-03 Positive Control (Tissue Lysate) Human Spleen
RF10001-02 Negative Control (Cell Lysate) Human HEK293
 
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Slides


Cat. No.Product TypeSpeciesNameDatasheet
RF10002-03 Positive Control (Tissue Lysate) Human Spleen
RF10002-02 Negative Control (Cell Lysate) Human HEK293
 
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Conjugates


Cat. No.HRPBiotinCustom
RF16082 Not Available Available Contact Us
RF16083 Not Available Available Contact Us
RF16084 Not Available Available Contact Us
RF16088 Not Available Available Contact Us
RF16089 Not Available Available Contact Us
 

Additional Antibody LAG-3 Products

Monoclonal antibodies are highly specific and recognize only one epitope on an antigen which generates consistent performance in quantitative detection applications regardless of production batch. Polyclonal antibodies have high affinity and recognize different epitopes on a specific antigen. Note: These antibodies can be stored at -20˚C and are stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.


Monoclonal LAG-3 Products

Cat. No.NameApplicationsDatasheet
36-105Host Species: Mouse
Reactivity:Human, Monkey
LAG-3 Antibody [11E3] ELISA, Func, ICC, IHC, IP, WB
36-106Host Species: Mouse
Reactivity: Human, Monkey
LAG-3 Antibody [11E3] (PE) ELISA, Func, ICC, IHC, IP, WB
36-107Host Species: Mouse
Reactivity: Human
LAG-3 Antibody [17B4] Func, ICC, IHC, IP, WB
36-108Host Species: Mouse
Reactivity: Human
LAG-3 Antibody [17B4] (PE) Func, ICC, IHC, IP, WB
36-109Host Species: Mouse
Reactivity: Human
LAG-3 Antibody [17B4] (biotin) ELISA
36-110Host Species: Human
Reactivity: Human
LAG-3 Antibody [17B4] (FITC) Flow
36-111Host Species: Mouse
Reactivity: Human
LAG-3 Antibody [17B4] (ATTO 590) ICC
36-112Host Species: Mouse
Reactivity: Human
LAG-3 Antibody [17B4] (ATTO 488) Flow, ICC
36-113Host Species: Mouse
Reactivity: Human
LAG-3 Antibody [17B4] (ATTO 647N) Flow, ICC

Polyclonal LAG-3 Products

Cat. No.NameApplicationsDatasheet
8655Host Species: Rabbit
Reactivity:Human, Mouse
LAG-3 Antibody ELISA, IF, IHC-P, WB
62-572Host Species: Rabbit
Reactivity: Human, Mouse
LAG3 Antibody IHC-P

Additional LAG-3 Information

 

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