Home /
Immune Checkpoints /
B7-H3 Immune Checkpoint | ProSci Inc

B7-H3 Immune Checkpoint

B7-H3 Antibody: CD276, also known as B7-H3, was initially identified as a member of the B7 family of proteins through its homology with previously identified B7 molecules (1). CD276 mRNA is widely expressed, but its protein expression is usually rather low (2). CD276 has been shown to play a role in both the costimulation as well as the coinhibition of T cell response (3). In a similar fashion, CD276 plays a critical role in the control of antitumor immune responses in some cases, while in others appears to mediate antitumor immunity (4). It thus joins other immune checkpoint proteins as a possible therapeutic target for at least a subset of cancers.

Risk-Free™ Mouse Monoclonal B7-H3 Products

ProSci's Risk-Free™ antibodies are monoclonal antibodies made to improve in vivo studies. Unlike antibodies developed using proteins made in yeast or bacteria, Risk-Free™ B7-H3 antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein. Risk-Free™ means they are guaranteed to work for their approved applications.
"Hover over research application to see respective image (if available)."

Risk-Free™ Mouse Monoclonal B7-H3 Set

ProSci's Risk-Free™ Sets consists of several mAbs with different binding features allowing selection of the best clone.

Product Set	Size	Contents	Description
Risk-Free B7-H3 Set (RF16090)	20μg / Clone	RF16091, RF16092, RF16093, RF16094, RF16095	Mouse monoclonal B7-H3 antibodies were raised against the extracellular domain of human B7-H3.

Risk-Free™ Mouse Monoclonal B7-H3 Antibodies

ProSci Risk-Free™ B7-H3 antibodies are rigorously tested and guaranteed to work for their designated applications.

= Negative = Fair = Average = Good = Excellent= Best Application
Cat. No.	ELISA	WB	ICC	IF	IHC	Flow	Conjugation
RF16091 Host Species: Mouse Reactivity: Human	ELISA Titration Curve Analysis	WB in HEK293 Cells	ICC in HEK293 Cells		IHC in Human Lymph Node	Flow in HEK293 Cells	Available
RF16092 Host Species: Mouse Reactivity: Human	ELISA Titration Curve Analysis	WB in HEK293 Cells	ICC in HEK293 Cells	IF in HEK293 Cells	IHC in Human Lymph Node	Flow in HEK293 Cells	Available
RF16093 Host Species: Mouse Reactivity: Human	ELISA Titration Curve Analysis	WB in HEK293 Cells	ICC in HEK293 Cells	IF in HEK293 Cells	IHC in Human Lymph Node	Flow in HEK293 Cells	Available
RF16094 Host Species: Mouse Reactivity: Human	ELISA Titration Curve Analysis		ICC in HEK293 Cells	IF in HEK293 Cells	IHC in Human Lymph Node	Flow in HEK293 Cells	Available
RF16095 Host Species: Mouse Reactivity: Human	ELISA Titration Curve Analysis		ICC in HEK293 Cells	IF in HEK293 Cells	IHC in Human Lymph Node	Flow in HEK293 Cells	Available

Risk-Free™ Single Domain Monoclonal B7-H3 Products

Llama single domain antibodies (sdAbs) offer unique characteristics amenable to many applications. These sdAbs demonstrate low nanomolar binding affinity and can be used for the various applications. Note: B7-H3 antibody should be stored in working aliquots at -20 °C, stable for up to one year. As with all antibodies, care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Not Available

If you are interested in developing a single domain antibody for this target, let us know.

Antigen

Cat. No.	Product Type	Species	Tissue/Cell	Datasheet
RF16090-01	Recombinant Protein	Human	HEK293	PDF

Lysates

Cat. No.	Product Type	Species	Name	Datasheet
RF10001-02	Negative Control (Cell Lysate)	Human	HEK293	PDF

Slides

Cat. No.	Product Type	Species	Name	Datasheet
RF10002-05	Positive Control (Tissue Lysate)	Human	Spleen	PDF

Conjugates

Cat. No.	HRP	Biotin	Custom
RF16091	Not Available	Not Available	Contact Us
RF16092	Not Available	Not Available	Contact Us
RF16093	Not Available	Not Available	Contact Us
RF16094	Not Available	Not Available	Contact Us
RF16095	Not Available	Not Available	Contact Us

Additional Antibody B7-H3 Products

Monoclonal antibodies are highly specific and recognize only one epitope on an antigen which generates consistent performance in quantitative detection applications regardless of production batch. Polyclonal antibodies have high affinity and recognize different epitopes on a specific antigen. Note: These antibodies can be stored at -20˚C and are stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.