B7-H3 Immune Checkpoint

 

B7-H3 Antibody: CD276, also known as B7-H3, was initially identified as a member of the B7 family of proteins through its homology with previously identified B7 molecules (1). CD276 mRNA is widely expressed, but its protein expression is usually rather low (2). CD276 has been shown to play a role in both the costimulation as well as the coinhibition of T cell response (3). In a similar fashion, CD276 plays a critical role in the control of antitumor immune responses in some cases, while in others appears to mediate antitumor immunity (4). It thus joins other immune checkpoint proteins as a possible therapeutic target for at least a subset of cancers.


Risk-Free™ Mouse Monoclonal B7-H3 Products

ProSci's Risk-Free™ antibodies are monoclonal antibodies made to improve in vivo studies. Unlike antibodies developed using proteins made in yeast or bacteria, Risk-Free™ B7-H3 antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein. Risk-Free™ means they are guaranteed to work for their approved applications.
"Hover over research application to see respective image (if available)."

Risk-Free™ Mouse Monoclonal B7-H3 Set

ProSci's Risk-Free™ Sets consists of several mAbs with different binding features allowing selection of the best clone.

Product SetSizeContentsDescription
Risk-Free B7-H3 Set (RF16090) 20μg / Clone RF16091, RF16092, RF16093, RF16094, RF16095 Mouse monoclonal B7-H3 antibodies were raised against the extracellular domain of human B7-H3.

Risk-Free™ Mouse Monoclonal B7-H3 Antibodies

ProSci Risk-Free™ B7-H3 antibodies are rigorously tested and guaranteed to work for their designated applications.

= Negative = Fair   = Average    = Good     = Excellent= Best Application
Cat. No.ELISAWBICCIFIHCFlowConjugation
RF16091 Host Species: Mouse
Reactivity: Human
   
ELISA Titration Curve Analysis

WB in HEK293 Cells
 
ICC in HEK293 Cells
    
IHC in Human Lymph Node
   
Flow in HEK293 Cells
Available
RF16092 Host Species: Mouse
Reactivity: Human
   
ELISA Titration Curve Analysis
   
WB in HEK293 Cells
   
ICC in HEK293 Cells
   
IF in HEK293 Cells
   
IHC in Human Lymph Node
   
Flow in HEK293 Cells
Available
RF16093 Host Species: Mouse
Reactivity: Human
   
ELISA Titration Curve Analysis
   
WB in HEK293 Cells
   
ICC in HEK293 Cells
   
IF in HEK293 Cells
   
IHC in Human Lymph Node
   
Flow in HEK293 Cells
Available
RF16094 Host Species: Mouse
Reactivity: Human
   
ELISA Titration Curve Analysis
      
ICC in HEK293 Cells
   
IF in HEK293 Cells
   
IHC in Human Lymph Node
   
Flow in HEK293 Cells
Available
RF16095 Host Species: Mouse
Reactivity: Human
   
ELISA Titration Curve Analysis
     
ICC in HEK293 Cells
  
IF in HEK293 Cells
  
IHC in Human Lymph Node
   
Flow in HEK293 Cells
Available

Risk-Free™ Single Domain Monoclonal B7-H3 Products

Llama single domain antibodies (sdAbs) offer unique characteristics amenable to many applications. These sdAbs demonstrate low nanomolar binding affinity and can be used for the various applications. Note: B7-H3 antibody should be stored in working aliquots at -20 °C, stable for up to one year. As with all antibodies, care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Not Available

If you are interested in developing a single domain antibody for this target, let us know.

Related Products

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Antigen


Cat. No.Product TypeSpeciesTissue/CellDatasheet
RF16090-01 Recombinant Protein Human HEK293
 
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Lysates


Cat. No.Product TypeSpeciesNameDatasheet
RF10001-02 Negative Control (Cell Lysate) Human HEK293
 
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Slides


Cat. No.Product TypeSpeciesNameDatasheet
RF10002-05 Positive Control (Tissue Lysate) Human Spleen
 
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Conjugates


Cat. No.HRPBiotinCustom
RF16091 Not Available Not Available Contact Us
RF16092 Not Available Not Available Contact Us
RF16093 Not Available Not Available Contact Us
RF16094 Not Available Not Available Contact Us
RF16095 Not Available Not Available Contact Us
 

Additional Antibody B7-H3 Products

Monoclonal antibodies are highly specific and recognize only one epitope on an antigen which generates consistent performance in quantitative detection applications regardless of production batch. Polyclonal antibodies have high affinity and recognize different epitopes on a specific antigen. Note: These antibodies can be stored at -20˚C and are stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.


Monoclonal B7-H3 Products

Cat. No.NameApplicationsDatasheet
51-061Host Species: Mouse
Reactivity:Human
CD276 Antibody [MIH42] Flow

Polyclonal B7-H3 Products

Cat. No.NameApplicationsDatasheet
8689Host Species: Rabbit
Reactivity:Human, Mouse, Rat
CD276 Antibody ELISA, IF, IHC-P, WB

Additional B7-H3 Information

 

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