Datasheet

IL-9 Antibody
CATALOG NUMBER: 7495

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Specifications
Properties
Additional Info
Background

Specifications

SPECIES REACTIVITY:Human
TESTED APPLICATIONS:ELISA, IF, IHC-P, WB
APPLICATIONS:IL-9 antibody can be used for detection of IL-9 by Western blot at 1 - 2 μg/ml.
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
POSITIVE CONTROL:1) Cat. No. 1306 - Human Spleen Tissue Lysate
 2) Cat. No. 10-901 - Human Spleen Tissue Slide
PREDICTED MOLECULAR WEIGHT:Predicted: 13 kDa

Observed: 22kDa
SPECIFICITY:IL-9 antibody is human specific. IL-9 antibody is predicted to no cross-react with IL-7.
IMMUNOGEN:IL-9 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human IL-9.

The immunogen is located within the last 50 amino acids of IL-9 .
HOST SPECIES:Rabbit

Properties

PURIFICATION:IL-9 Antibody is affinity chromatography purified via peptide column.
PHYSICAL STATE:Liquid
BUFFER:IL-9 Antibody is supplied in PBS containing 0.02% sodium azide.
CONCENTRATION:1 mg/mL
STORAGE CONDITIONS:IL-9 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
CLONALITY:Polyclonal
ISOTYPE:IgG
CONJUGATE:Unconjugated

Additional Info

ALTERNATE NAMES:IL-9 Antibody : P40, HP40, IL-9, Interleukin-9, Cytokine P40
ACCESSION NO.:NP_000581
PROTEIN GI NO.:10834980
OFFICIAL SYMBOL:IL9
GENE ID:3578

Background

BACKGROUND:Interleukin 9 (IL-9) is a cytokine secreted by TH2 lymphocytes that acts as a regulator of a variety of hematopoietic cells, stimulates cell proliferation and prevents apoptosis (1,2). It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins (3). The IL-9 gene has been identified as a candidate gene for asthma (4). Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness (5).
REFERENCES: 1) Renauld JC, Goethals A, Houssiau F, et al. Cloning and expression of a cDNA for the human homolog of mouse T cell and mast cell growth factor P40. Cytokine 1990; 2:9-12.
2) Tete S, Saggini A, Maccauro G, et al. Interleukin-9 and mast cells. J. Biol. Homeost. Agents 2012; 26:319-26.
3) Knoops L and Renauld JC. IL-9 and its receptor: from signal transduction to tumorigenesis. Growth Factors 2004; 22:207-15.
4) Nicolaides NC, Holroyd KJ, Ewart SL, et al. Interleukin 9: a candidate gene for asthma. Proc. Natl. Acad. Sci. USA 1997; 94:13175-80.

For Research Use Only