IL-6 Antibody [2M8M3] Cat. No.: 11-094

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psi-iconSpecifications
HOST SPECIES:Rabbit
SPECIES REACTIVITY: Virus
IMMUNOGEN: E. coli-derived human IL-6 protein, amino acids Pro29-Met212
TESTED APPLICATIONS: ELISA
APPLICATIONS: Human IL-6 Sandwich Immunoassay:

ELISA Capture: Recommended Concentration: 1-4ug/mL, Sample: Human IL-6 Monoclonal Antibody, Rabbit MAb(CAP)

ELISA Detection: Recommended Concentration: 0.03-0.15ug/mL, Sample: Human IL-6 Monoclonal Antibody, Rabbit MAb(DET)

Standard: Recommended Concentration: 0.78-50pg/mL, Sample: Recombinant Human IL6 Protein


psi-iconProperties
PURIFICATION:Affinity Purified, Endotoxin Level: < 1.0 EU/ug of the protein by LAL method.
CLONALITY:Monoclonal
ISOTYPE:Rabbit IgG
CONJUGATE:Unconjugated
PHYSICAL STATE:Liquid
BUFFER:Supplied as a 0.2um filtered solution in PBS, pH 7.4.
CONCENTRATION:1mg/ml
STORAGE CONDITIONS:This antibody can be stored at 2˚C to -8˚C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20˚C to -80˚C. Preservative-Free. Avoid repeated freeze-thaw cycles.

psi-iconAdditional Info
OFFICIAL SYMBOL:IL6
ALTERNATE NAMES:CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2
PROTEIN GI NO.:74739144
GENE ID:3569
USER NOTE:Optimal dilutions for each application to be determined by the researcher.
psi-iconBackground and References
BACKGROUND:Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway (Probable). The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells (Probable).

ANTIBODIES FOR RESEARCH USE ONLY.

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